- published: 14 Jul 2014
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Niels Kaj Jerne, FRS (December 23, 1911 – October 7, 1994) was a Danish immunologist. He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "[f]or theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies".
Jerne is known for three significant ideas. First, instead of the body creating antibodies in response to an antigen, Jerne postulated that the immune system already has the specific antibodies it needs to fight antigens. Second, it was known that the immune system learns to be tolerant to the individual's own self. Jerne postulated that this learning took place in the thymus. Third, it was known that T cells and B cells communicate with each other. Jerne's network theory proposed that the active sites of antibodies were attracted to both specific antigens (idiotypes) and to other antibodies that were bound to the same site. The antibodies were in balance, until an antigen disturbed the balance, creating an immune reaction.