Col. Yuri Ivanovich Onufriyenko (Russian: Юрий Иванович Онуфриенко, Ukrainian: Юрій Іванович Онуфрієнко) (born 6 February 1961) is a Russian cosmonaut. He is a veteran of two extended spaceflights, aboard the space station Mir in 1996 and aboard the International Space Station in 2001-2002.

Onufriyenko was born in Ryasne, Zolochiv Raion of Kharkiv Oblast, Soviet Union (now Ukraine). Onufriyenko and his wife, Valentina Mikhailovna Onufrienko, have two sons, Yuri, born in 1982 and Aleksandr, born in 1990 and one daughter, Elena, born in 1988. He has two older brothers and his parents are deceased. Onufriyenko enjoys tennis, cooking, fishing, chess, and aviation.

Onufriyenko graduated from the V.M. Komarov Eisk Higher Military Aviation School for Pilots in 1982 with a pilot-engineer's diploma. In 1994, Onufriyenko earned a degree in cartography from Moscow State University.

Onufriyenko was award the Hero of Russia medal, the title of Pilot-Cosmonaut of the Russian Federation, the Gold Star Medal of the Hero of the Russian Federation and NASA Space Flight and Public Service Medals. In 1997 he was named a Chevalier in the French Legion of Honor.