Pierre Eugène Jean Pflimlin (French pronunciation: [pjɛʁ flimlɛ̃]; 5 February 1907 – 27 June 2000) was a French Christian democratic politician who served as the penultimate Prime Minister of the Fourth Republic for a few weeks in 1958, before being replaced by Charles de Gaulle during the crisis of that year.

Pfilimlin was born in Roubaix in the département Nord.

A lawyer and a member of the Christian democratic Popular Republican Movement (MRP), he was elected deputy of département Bas Rhin in 1945. With his personal roots in Alsace, Pflimlin numbered among his MRP party colleagues the Luxembourg-born Robert Schuman; for both, relations with Germany played an important role in their political thinking.

He held some governmental offices during the Fourth Republic, notably as Minister of Agriculture (1947–1949 and 1950–1951) and as Minister of Economy and Finance (1955–1956 and 1957–1958).

In 13 May 1958, the French National Assembly approved his nomination as Prime Minister. But the same day, riots took place in Algiers. The French generals in Algeria expected him to search for a negotiated solution with the Algerian nationalists and refused to recognize his cabinet. The crisis brought Charles de Gaulle to the head of the cabinet on 1 June.