Francisco de Sande Picón (1540–1627) was the third Spanish governor and captain-general of the Philippines from August 25, 1575 to April 1580.

A native of Cáceres, served as attorney, criminal judge, and auditor in Mexico. He succeed Guido de Lavezaris, a member of the 1543 Ruy López de Villalobos Expedition from Barra de Navidad, Jalisco, México, on August 25, 1575.

In 1575, King Philip II of Spain appointed him as the governor-general of the Philippines.

One of his first political advocacy was to disestablish vast encomiendas of wealthy Spaniards in the Philippines. In 1576, he issued a decree forbidding all officials appointed by the Crown to own encomiendas that are initially for Indios. He also established the city of Nueva Cáceres, province of Camarines Sur, Bicol region, Island of Luzon, the largest of the some 7107 islands (under Spanish Administration till 1898, for some 350–370 years), Philippine Islands. A few years after, Spanish and Dominican prelate Domingo de Salazar requested to create monasteries for the Dominicans which was granted by Sande through King Philip II's royal decree.