Würzburg (German pronunciation: [ˈvʏɐ̯tsbʊɐ̯k]; Main-Franconian: Wörtzburch) is a city in the region of Franconia, Northern Bavaria, Germany. Located on the Main River, it is the capital of the Regierungsbezirk Lower Franconia. The regional dialect is Franconian.

Würzburg lies at about equal distance (120 kilometer, or 75 miles) between Frankfurt am Main and Nuremberg. Although the city of Würzburg is not part of the Landkreis Würzburg, i.e the county or district of Würzburg, it is the seat of the district's administration. The city's population is 133,501 as of 31 December 2008.

A Bronze Age (Urnfield culture) refuge castle stood on the site of the present Fortress Marienberg. The former Celtic territory was settled by the Alamanni in the 4th or 5th century, and by the Franks in the 6th to 7th. Würzburg was a Merovingian seat from about 650, Christianized in 686 by Irish missionaries Kilian, Kolonat and Totnan. The city is mentioned in a donation by Hedan II to bishop Willibrord, dated 1 May 704, in castellum Virteburch. The Ravenna Cosmography lists the city as Uburzis at about the same time. The name is presumably of Celtic origin, but based on a folk etymological connection to the German word Würze "herb, spice", the name was Latinized as Herbipolis in the medieval period. Beginning in 1237, the city seal depicted the cathedral and a portrait of Saint Kilian, with the inscription SIGILLVM CIVITATIS HERBIPOLENSIS.