Endothelin 1

Endothelin 1
	Rendering of 1EDN
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Symbols	EDN1 ; ARCND3; ET1; HDLCQ7; PPET1; QME
External IDs	OMIM: 131240 MGI: 95283 HomoloGene: 1476 GeneCards: EDN1 Gene
Gene ontology
Molecular function	• cytokine activity; • hormone activity; • protein binding; • endothelin A receptor binding; • endothelin B receptor binding;
Cellular component	• extracellular region; • extracellular space; • cytoplasm; • cytosol; • Weibel-Palade body; • basal part of cell; • rough endoplasmic reticulum lumen;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • prostaglandin biosynthetic process; • patterning of blood vessels; • in utero embryonic development; • histamine secretion; • regulation of systemic arterial blood pressure by endothelin; • regulation of pH; • cell surface receptor signaling pathway; • G-protein coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • protein kinase C-activating G-protein coupled receptor signaling pathway; • cell-cell signaling; • heart development; • respiratory gaseous exchange; • body fluid secretion; • positive regulation of cell proliferation; • dorsal/ventral pattern formation; • response to ozone; • multicellular organismal aging; • positive regulation of heart rate; • positive regulation of endothelial cell migration; • positive regulation of cardiac muscle hypertrophy; • positive regulation of receptor biosynthetic process; • neural crest cell development; • phosphatidylinositol 3-kinase signaling; • response to activity; • artery smooth muscle contraction; • vein smooth muscle contraction; • glucose transport; • cell growth; • regulation of vasoconstriction; • sensory perception of pain; • calcium-mediated signaling; • peptide hormone secretion; • nitric oxide transport; • negative regulation of blood coagulation; • positive regulation of cell migration; • neutrophil chemotaxis; • negative regulation of cAMP biosynthetic process; • phospholipase D-activating G-protein coupled receptor signaling pathway; • negative regulation of cellular protein metabolic process; • positive regulation of prostaglandin secretion; • response to lipopolysaccharide; • response to testosterone; • negative regulation of smooth muscle cell apoptotic process; • response to prostaglandin F; • response to nicotine; • cellular response to drug; • positive regulation of urine volume; • positive regulation of renal sodium excretion; • response to muscle stretch; • epithelial fluid transport; • vasoconstriction; • protein kinase C deactivation; • middle ear morphogenesis; • positive regulation of odontogenesis; • superoxide anion generation; • rhythmic excitation; • response to amino acid; • positive regulation of MAP kinase activity; • positive regulation of JUN kinase activity; • response to leptin; • leukocyte activation; • positive regulation of nitric oxide biosynthetic process; • positive regulation of cell size; • positive regulation of mitotic nuclear division; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of smooth muscle contraction; • positive regulation of hormone secretion; • negative regulation of hormone secretion; • inositol phosphate-mediated signaling; • positive regulation of smooth muscle cell proliferation; • cartilage development; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; • negative regulation of nitric-oxide synthase biosynthetic process; • membrane depolarization; • regulation of sensory perception of pain; • maternal process involved in parturition; • positive regulation of sarcomere organization; • positive regulation of prostaglandin-endoperoxide synthase activity; • positive regulation of chemokine-mediated signaling pathway; • cellular response to calcium ion; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • cellular response to peptide hormone stimulus; • cellular response to glucocorticoid stimulus; • cellular response to mineralocorticoid stimulus; • cellular response to fatty acid; • cellular response to hypoxia; • response to dexamethasone; • cellular response to transforming growth factor beta stimulus; • positive regulation of neutrophil chemotaxis; • response to salt;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1).

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[1]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References[edit]

^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

Endothelin 1

References[edit]

Further reading[edit]

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