MTA2

This article is about proteins. For the Islamic TV channel, see MTA 2.

Metastasis associated 1 family, member 2
Identifiers
Symbols	MTA2 ; MTA1L1; PID
External IDs	OMIM: 603947 MGI: 1346340 HomoloGene: 3480 GeneCards: MTA2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcription factor binding transcription factor activity • RNA polymerase II transcription factor binding • RNA polymerase II repressing transcription factor binding • sequence-specific DNA binding transcription factor activity • histone deacetylase activity • protein binding • zinc ion binding • nucleosomal DNA binding Cellular component • histone deacetylase complex • nuclear chromatin • nucleoplasm • transcription factor complex • membrane • NuRD complex • protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • DNA methylation • chromatin organization • chromatin assembly or disassembly • regulation of fibroblast migration • histone deacetylation • ATP-dependent chromatin remodeling • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9219	23942
Ensembl	ENSG00000149480	ENSMUSG00000071646
UniProt	O94776	Q9R190
RefSeq (mRNA)	NM_004739	NM_011842
RefSeq (protein)	NP_004730	NP_035972
Location (UCSC)	Chr 11: 62.59 – 62.6 Mb	Chr 19: 8.94 – 8.95 Mb
PubMed search	[1]	[2]

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

Function

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Interactions

MTA2 has been shown to interact with:

• CHD4,
• HDAC1,
• Histone deacetylase 2,
• MBD3
• MTA1,
• RBBP4,
• RBBP7, and
• SATB1.

Further reading

• Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (Oct 1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell 95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534. 
• Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (Oct 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427. 
• Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W (Dec 1998). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities". Molecular Cell 2 (6): 851–61. doi:10.1016/S1097-2765(00)80299-3. PMID 9885572. 
• Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591. 
• Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (Sep 1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nature Genetics 23 (1): 62–6. doi:10.1038/12664. PMID 10471500. 
• Luo J, Su F, Chen D, Shiloh A, Gu W (Nov 2000). "Deacetylation of p53 modulates its effect on cell growth and apoptosis". Nature 408 (6810): 377–81. doi:10.1038/35042612. PMID 11099047. 
• Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (Mar 2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". The Journal of Biological Chemistry 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443. 
• Feng Q, Zhang Y (Apr 2001). "The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes". Genes & Development 15 (7): 827–32. doi:10.1101/gad.876201. PMC 312663. PMID 11297506. 
• Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes & Development 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609. 
• Saito M, Ishikawa F (Sep 2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". The Journal of Biological Chemistry 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384. 
• Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985. 
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763. 
• Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA (Apr 2003). "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell 113 (2): 207–19. doi:10.1016/S0092-8674(03)00234-4. PMID 12705869. 
• Yao YL, Yang WM (Oct 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132. 
• Zoltewicz JS, Stewart NJ, Leung R, Peterson AS (Jan 2004). "Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis". Development 131 (1): 3–14. doi:10.1242/dev.00908. PMID 14645126. 
• Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M (Feb 2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell 116 (3): 445–56. doi:10.1016/S0092-8674(04)00117-5. PMID 15016378. 
• Jiang CL, Jin SG, Pfeifer GP (Dec 2004). "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex". The Journal of Biological Chemistry 279 (50): 52456–64. doi:10.1074/jbc.M409149200. PMID 15456747. 

External links

• MTA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.