- published: 11 Oct 2013
- views: 60270
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Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/ruffinis-ending-and-hair-follicle-receptor-2?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
“While we have known that capsaicin binds to the TRPV1 receptor with exquisite potency and selectivity, we were missing important atomic-level details about exactly how the capsaicin molecule interacts with TRPV1, one of the body’s primary receptors for sensing pain and heat,” said Jie Zheng, professor of physiology and membrane biology at UC Davis and an author on the paper.
Using computer models based on atomic force fields and existing low resolution 3-D reconstruction of TRPV1-capsaicin complex from cryo-electron microscopy (cryo-EM) studies, the researchers identified several structural areas that enable capsaicin to strongly bind to the TRPV1 receptor.
A news release and link to the research study, published in Nature Chemical BIology June 8, is available on UC Davis Health System's newsroom at https://www.ucdmc.ucdavis.edu/publish/news/newsroom/10074.
- published: 09 Jun 2015
- views: 2181
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers.
http://bit.ly/2bQ60W4
- published: 06 Sep 2016
- views: 679
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are debated. To address these fundamental issues, we searched for channel mutations that selectively affected one form of activation. We found that deletion of the first 10 amino acids of the pore turret significantly reduced the heat response amplitude and shifted the heat activation threshold, whereas capsaicin activation remained unchanged. Removing larger portions of the turret disrupted channel function. Introducing an artificial sequence to replace the deleted region restored sensitive capsaicin activation in these nonfunctional channels. The heat activation, however, remained significantly impaired, with the current exhibiting diminishing heat sensitivity to a level indistinguishable from that of a voltage-gated potassium channel, Kv7.4. Our results demonstrate that heat and capsaicin activation of TRPV1 are structurally and mechanistically distinct processes, and the pore turret is an indispensible channel structure involved in the heat activation process but is not part of the capsaicin activation pathway. Synergistic effect of heat and capsaicin on TRPV1 activation may originate from convergence of the two pathways on a common activation gate.
- published: 26 Jul 2012
- views: 2460
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled
In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a watershed for the field of structural biology, which aims to discover how proteins are physically constructed in order to better understand their function.
- published: 04 Dec 2013
- views: 4393
Subscribe! http://bit.ly/ACSReactions
You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this painful fire in your mouth? The short answer is capsaicin. But what exactly is capsaicin? How does it work? Why do people drink milk and not water to relieve the pain? Reactions has the chemistry to answer all of these sizzling questions.
Find us on all these places:
Subscribe! http://bit.ly/ACSReactions
Facebook! http://facebook.com/ACSReactions
Twitter! http://twitter.com/ACSReactions
Tumblr! http://tumblr.com/ACSReactions
Old School - Funk It Up
The Drive
Producer:
Elaine Seward
Writer:
Elaine Seward
Executive Producer:
Adam Dylewski
Scientific consultants:
Todd Brethauer
Sophia Cai
Darcy Gentleman, Ph.D.
Sources:
Milk - http://www.acs.org/content/acs/en/education/resources/highschool/chemmatters/past-issues/archive-2013-2014/peppers.html
Capsaicin and Pain - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302858/
Pain Receptors - http://www.nature.com/nature/journal/v389/n6653/full/389816a0.html#B5
- published: 01 Dec 2015
- views: 219341
Khan Academy
Khan Academy is a non-profit educational organization created in 2006 by educator Salman Khan with the aim of providing a free, world-class education for anyone, anywhere. The organization produces short lectures in the form of YouTube videos. In addition to micro lectures, the organization's website features practice exercises and tools for educators. All resources are available for free to anyone around the world. The main language of the website is English, but the content is also available in other languages.
History
The founder of the organization, Salman Khan, was born in New Orleans, Louisiana, United States to immigrant parents from Bangladesh and India. After earning three degrees from the Massachusetts Institute of Technology (a BS in mathematics, a BS in electrical engineering and computer science, and an MEng in electrical engineering and computer science), he pursued an MBA from Harvard Business School.
In late 2004, Khan began tutoring his cousin Nadia who needed help with math using Yahoo!'s Doodle notepad.When other relatives and friends sought similar help, he decided that it would be more practical to distribute the tutorials on YouTube. The videos' popularity and the testimonials of appreciative students prompted Khan to quit his job in finance as a hedge fund analyst at Connective Capital Management in 2009, and focus on the tutorials (then released under the moniker "Khan Academy") full-time.
This page contains text from Wikipedia, the Free Encyclopedia -
https://wn.com/Khan_Academy
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
TRPV1
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels.
The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception).
Function
TRPV1 is a nonselective cation channel that may be activated by a wide variety of exogenous and endogenous physical and chemical stimuli. The best-known activators of TRPV1 are: temperature greater than 43 °C (109 °F); acidic conditions; capsaicin, the irritating compound in hot chili peppers; and allyl isothiocyanate, the pungent compound in mustard and wasabi. The activation of TRPV1 leads to a painful, burning sensation. Its endogenous activators include: low pH (acidic conditions), the endocannabinoid anandamide, N-oleyl-dopamine, and N-arachidonoyl-dopamine. TRPV1 receptors are found mainly in the nociceptive neurons of the peripheral nervous system, but they have also been described in many other tissues, including the central nervous system. TRPV1 is involved in the transmission and modulation of pain (nociception), as well as the integration of diverse painful stimuli.
This page contains text from Wikipedia, the Free Encyclopedia -
https://wn.com/TRPV1
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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9:22Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan AcademyPain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/ruffinis-ending-and-hair-follicle-receptor-2?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy -
7:40TRPV1 Ion channels
TRPV1 Ion channelsTRPV1 Ion channels
-
0:07Capsaicin binding to its receptor TRPV1
Capsaicin binding to its receptor TRPV1Capsaicin binding to its receptor TRPV1
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain. “While we have known that capsaicin binds to the TRPV1 receptor with exquisite potency and selectivity, we were missing important atomic-level details about exactly how the capsaicin molecule interacts with TRPV1, one of the body’s primary receptors for sensing pain and heat,” said Jie Zheng, professor of physiology and membrane biology at UC Davis and an author on the paper. Using computer models based on atomic force fields and existing low resolution 3-D reconstruction of TRPV1-capsaicin complex from cryo-electron microscopy (cryo-EM) studies, the researchers identified several structural areas that enable capsaicin to strongly bind to the TRPV1 receptor. A news release and link to the research study, published in Nature Chemical BIology June 8, is available on UC Davis Health System's newsroom at https://www.ucdmc.ucdavis.edu/publish/news/newsroom/10074. -
3:09GABA puts the brakes on TRPV1
GABA puts the brakes on TRPV1GABA puts the brakes on TRPV1
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers. http://bit.ly/2bQ60W4 -
7:25Pore turret in TRPV1 heat activation - Cui et al.
Pore turret in TRPV1 heat activation - Cui et al.Pore turret in TRPV1 heat activation - Cui et al.
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are debated. To address these fundamental issues, we searched for channel mutations that selectively affected one form of activation. We found that deletion of the first 10 amino acids of the pore turret significantly reduced the heat response amplitude and shifted the heat activation threshold, whereas capsaicin activation remained unchanged. Removing larger portions of the turret disrupted channel function. Introducing an artificial sequence to replace the deleted region restored sensitive capsaicin activation in these nonfunctional channels. The heat activation, however, remained significantly impaired, with the current exhibiting diminishing heat sensitivity to a level indistinguishable from that of a voltage-gated potassium channel, Kv7.4. Our results demonstrate that heat and capsaicin activation of TRPV1 are structurally and mechanistically distinct processes, and the pore turret is an indispensible channel structure involved in the heat activation process but is not part of the capsaicin activation pathway. Synergistic effect of heat and capsaicin on TRPV1 activation may originate from convergence of the two pathways on a common activation gate. -
0:33Structure of Key Pain-Related Protein TRPV1 Unveiled
Structure of Key Pain-Related Protein TRPV1 UnveiledStructure of Key Pain-Related Protein TRPV1 Unveiled
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat. Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a watershed for the field of structural biology, which aims to discover how proteins are physically constructed in order to better understand their function. -
10:32Proton-induced TRPV1 OFF response-Lee and Zheng
Proton-induced TRPV1 OFF response-Lee and Zheng -
12:17Nociceptors - An Introduction to Pain
Nociceptors - An Introduction to Pain -
0:33TRPV1
TRPV1TRPV1
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4:28Why Do Hot Peppers Cause Pain?
Why Do Hot Peppers Cause Pain?Why Do Hot Peppers Cause Pain?
Subscribe! http://bit.ly/ACSReactions You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this painful fire in your mouth? The short answer is capsaicin. But what exactly is capsaicin? How does it work? Why do people drink milk and not water to relieve the pain? Reactions has the chemistry to answer all of these sizzling questions. Find us on all these places: Subscribe! http://bit.ly/ACSReactions Facebook! http://facebook.com/ACSReactions Twitter! http://twitter.com/ACSReactions Tumblr! http://tumblr.com/ACSReactions Old School - Funk It Up The Drive Producer: Elaine Seward Writer: Elaine Seward Executive Producer: Adam Dylewski Scientific consultants: Todd Brethauer Sophia Cai Darcy Gentleman, Ph.D. Sources: Milk - http://www.acs.org/content/acs/en/education/resources/highschool/chemmatters/past-issues/archive-2013-2014/peppers.html Capsaicin and Pain - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302858/ Pain Receptors - http://www.nature.com/nature/journal/v389/n6653/full/389816a0.html#B5
-
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/ruffinis-ending-and-hair-follicle-receptor-2?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us...
published: 11 Oct 2013 -
TRPV1 Ion channels
published: 25 May 2015 -
Capsaicin binding to its receptor TRPV1
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain. “While we have known that capsaicin binds to the TRPV1 receptor with exquisite potency and selectivity, we were missing important atomic-level details about exactly how the capsaicin molecule interacts with TRPV1, one of the body’s primary receptors for sensing pain and heat,” said Jie Zheng, professor of physiology and membrane biology at UC Davis and an author on the paper. Using computer models based on atomic force fields and existing low resolution 3-D reconstruction of TRPV1-capsaicin complex from cryo-electron microscopy (cryo-EM) studies, the rese...
published: 09 Jun 2015 -
GABA puts the brakes on TRPV1
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers. http://bit.ly/2bQ60W4
published: 06 Sep 2016 -
Pore turret in TRPV1 heat activation - Cui et al.
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are debated. To address these fundamental issues, we searched for channel mutations that selectively affected one form of activation. We found that deletion of the first 10 amino acids of the pore turret significantly reduced the heat response amplitude and shifted the heat activation threshold, whereas capsaicin activation remained unchanged. Removing larger portions of the turret disrup...
published: 26 Jul 2012 -
Structure of Key Pain-Related Protein TRPV1 Unveiled
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat. Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a watershed for the field of structural biology, which aims to discover how proteins are physically constructed in order to better understand their function.
published: 04 Dec 2013 -
-
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TRPV1
published: 16 Dec 2015 -
Why Do Hot Peppers Cause Pain?
Subscribe! http://bit.ly/ACSReactions You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this painful fire in your mouth? The short answer is capsaicin. But what exactly is capsaicin? How does it work? Why do people drink milk and not water to relieve the pain? Reactions has the chemistry to answer all of these sizzling questions. Find us on all these places: Subscribe! http://bit.ly/ACSReactions Facebook! http://facebook.com/ACSReactions Twitter! http://twitter.com/ACSReactions Tumblr! http://tumblr.com/ACSReactions Old School - Funk It Up The Drive Producer: Elaine Seward Writer: Elaine Seward Executive Producer: Adam Dylewski Scientific consultants: Todd Brethauer Sophia Cai Darcy Gentleman, Ph.D. Sources: Milk - ht...
published: 01 Dec 2015
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
- Order: Reorder
- Duration: 9:22
- Updated: 11 Oct 2013
- views: 60270
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integu...
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/ruffinis-ending-and-hair-follicle-receptor-2?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
https://wn.com/Pain_And_Temperature_|_Integumentary_System_Physiology_|_Nclex_Rn_|_Khan_Academy
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/ruffinis-ending-and-hair-follicle-receptor-2?utm_source=YT&utm;_medium=Desc&utm;_campaign=Nclex-rn
NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
- published: 11 Oct 2013
- views: 60270
TRPV1 Ion channels
- Order: Reorder
- Duration: 7:40
- Updated: 25 May 2015
- views: 1430
- published: 25 May 2015
- views: 1430
Capsaicin binding to its receptor TRPV1
- Order: Reorder
- Duration: 0:07
- Updated: 09 Jun 2015
- views: 2181
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving t...
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
“While we have known that capsaicin binds to the TRPV1 receptor with exquisite potency and selectivity, we were missing important atomic-level details about exactly how the capsaicin molecule interacts with TRPV1, one of the body’s primary receptors for sensing pain and heat,” said Jie Zheng, professor of physiology and membrane biology at UC Davis and an author on the paper.
Using computer models based on atomic force fields and existing low resolution 3-D reconstruction of TRPV1-capsaicin complex from cryo-electron microscopy (cryo-EM) studies, the researchers identified several structural areas that enable capsaicin to strongly bind to the TRPV1 receptor.
A news release and link to the research study, published in Nature Chemical BIology June 8, is available on UC Davis Health System's newsroom at https://www.ucdmc.ucdavis.edu/publish/news/newsroom/10074.
https://wn.com/Capsaicin_Binding_To_Its_Receptor_Trpv1
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
“While we have known that capsaicin binds to the TRPV1 receptor with exquisite potency and selectivity, we were missing important atomic-level details about exactly how the capsaicin molecule interacts with TRPV1, one of the body’s primary receptors for sensing pain and heat,” said Jie Zheng, professor of physiology and membrane biology at UC Davis and an author on the paper.
Using computer models based on atomic force fields and existing low resolution 3-D reconstruction of TRPV1-capsaicin complex from cryo-electron microscopy (cryo-EM) studies, the researchers identified several structural areas that enable capsaicin to strongly bind to the TRPV1 receptor.
A news release and link to the research study, published in Nature Chemical BIology June 8, is available on UC Davis Health System's newsroom at https://www.ucdmc.ucdavis.edu/publish/news/newsroom/10074.
- published: 09 Jun 2015
- views: 2181
GABA puts the brakes on TRPV1
- Order: Reorder
- Duration: 3:09
- Updated: 06 Sep 2016
- views: 679
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecul...
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers.
http://bit.ly/2bQ60W4
https://wn.com/Gaba_Puts_The_Brakes_On_Trpv1
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers.
http://bit.ly/2bQ60W4
- published: 06 Sep 2016
- views: 679
Pore turret in TRPV1 heat activation - Cui et al.
- Order: Reorder
- Duration: 7:25
- Updated: 26 Jul 2012
- views: 2460
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation o...
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are debated. To address these fundamental issues, we searched for channel mutations that selectively affected one form of activation. We found that deletion of the first 10 amino acids of the pore turret significantly reduced the heat response amplitude and shifted the heat activation threshold, whereas capsaicin activation remained unchanged. Removing larger portions of the turret disrupted channel function. Introducing an artificial sequence to replace the deleted region restored sensitive capsaicin activation in these nonfunctional channels. The heat activation, however, remained significantly impaired, with the current exhibiting diminishing heat sensitivity to a level indistinguishable from that of a voltage-gated potassium channel, Kv7.4. Our results demonstrate that heat and capsaicin activation of TRPV1 are structurally and mechanistically distinct processes, and the pore turret is an indispensible channel structure involved in the heat activation process but is not part of the capsaicin activation pathway. Synergistic effect of heat and capsaicin on TRPV1 activation may originate from convergence of the two pathways on a common activation gate.
https://wn.com/Pore_Turret_In_Trpv1_Heat_Activation_Cui_Et_Al.
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are debated. To address these fundamental issues, we searched for channel mutations that selectively affected one form of activation. We found that deletion of the first 10 amino acids of the pore turret significantly reduced the heat response amplitude and shifted the heat activation threshold, whereas capsaicin activation remained unchanged. Removing larger portions of the turret disrupted channel function. Introducing an artificial sequence to replace the deleted region restored sensitive capsaicin activation in these nonfunctional channels. The heat activation, however, remained significantly impaired, with the current exhibiting diminishing heat sensitivity to a level indistinguishable from that of a voltage-gated potassium channel, Kv7.4. Our results demonstrate that heat and capsaicin activation of TRPV1 are structurally and mechanistically distinct processes, and the pore turret is an indispensible channel structure involved in the heat activation process but is not part of the capsaicin activation pathway. Synergistic effect of heat and capsaicin on TRPV1 activation may originate from convergence of the two pathways on a common activation gate.
- published: 26 Jul 2012
- views: 2460
Structure of Key Pain-Related Protein TRPV1 Unveiled
- Order: Reorder
- Duration: 0:33
- Updated: 04 Dec 2013
- views: 4393
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled
In a technical tour de force, UC San Francisco (UCSF) scientists have deter...
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled
In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a watershed for the field of structural biology, which aims to discover how proteins are physically constructed in order to better understand their function.
https://wn.com/Structure_Of_Key_Pain_Related_Protein_Trpv1_Unveiled
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled
In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a watershed for the field of structural biology, which aims to discover how proteins are physically constructed in order to better understand their function.
- published: 04 Dec 2013
- views: 4393
Proton-induced TRPV1 OFF response-Lee and Zheng
- Order: Reorder
- Duration: 10:32
- Updated: 09 Nov 2015
- views: 328
H+ not only activates the TRPV1 cation channel but inhibits ion permeation, yielding a prominent OFF current response.
H+ not only activates the TRPV1 cation channel but inhibits ion permeation, yielding a prominent OFF current response.
https://wn.com/Proton_Induced_Trpv1_Off_Response_Lee_And_Zheng
Nociceptors - An Introduction to Pain
- Order: Reorder
- Duration: 12:17
- Updated: 13 Aug 2013
- views: 417397
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https://wn.com/Nociceptors_An_Introduction_To_Pain
TRPV1
- Order: Reorder
- Duration: 0:33
- Updated: 16 Dec 2015
- views: 163
- published: 16 Dec 2015
- views: 163
Why Do Hot Peppers Cause Pain?
- Order: Reorder
- Duration: 4:28
- Updated: 01 Dec 2015
- views: 219341
Subscribe! http://bit.ly/ACSReactions
You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this pain...
Subscribe! http://bit.ly/ACSReactions
You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this painful fire in your mouth? The short answer is capsaicin. But what exactly is capsaicin? How does it work? Why do people drink milk and not water to relieve the pain? Reactions has the chemistry to answer all of these sizzling questions.
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Old School - Funk It Up
The Drive
Producer:
Elaine Seward
Writer:
Elaine Seward
Executive Producer:
Adam Dylewski
Scientific consultants:
Todd Brethauer
Sophia Cai
Darcy Gentleman, Ph.D.
Sources:
Milk - http://www.acs.org/content/acs/en/education/resources/highschool/chemmatters/past-issues/archive-2013-2014/peppers.html
Capsaicin and Pain - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302858/
Pain Receptors - http://www.nature.com/nature/journal/v389/n6653/full/389816a0.html#B5
https://wn.com/Why_Do_Hot_Peppers_Cause_Pain
Subscribe! http://bit.ly/ACSReactions
You have probably had the burning sensation of eating a hot jalapeno or other tear-inducing pepper. What causes this painful fire in your mouth? The short answer is capsaicin. But what exactly is capsaicin? How does it work? Why do people drink milk and not water to relieve the pain? Reactions has the chemistry to answer all of these sizzling questions.
Find us on all these places:
Subscribe! http://bit.ly/ACSReactions
Facebook! http://facebook.com/ACSReactions
Twitter! http://twitter.com/ACSReactions
Tumblr! http://tumblr.com/ACSReactions
Old School - Funk It Up
The Drive
Producer:
Elaine Seward
Writer:
Elaine Seward
Executive Producer:
Adam Dylewski
Scientific consultants:
Todd Brethauer
Sophia Cai
Darcy Gentleman, Ph.D.
Sources:
Milk - http://www.acs.org/content/acs/en/education/resources/highschool/chemmatters/past-issues/archive-2013-2014/peppers.html
Capsaicin and Pain - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302858/
Pain Receptors - http://www.nature.com/nature/journal/v389/n6653/full/389816a0.html#B5
- published: 01 Dec 2015
- views: 219341
- Playlist
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9:22
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
Explore our senses of pain & temperature. By Ron. Created by Ronald Sahyouni.
Watch the...
published: 11 Oct 2013
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
Pain and temperature | Integumentary system physiology | NCLEX-RN | Khan Academy
- Report rights infringement
- published: 11 Oct 2013
- views: 60270
7:40
TRPV1 Ion channels
published: 25 May 2015
TRPV1 Ion channels
TRPV1 Ion channels
- Report rights infringement
- published: 25 May 2015
- views: 1430
0:07
Capsaicin binding to its receptor TRPV1
UC Davis researchers have identified the molecular interactions that allow capsaicin to ac...
published: 09 Jun 2015
Capsaicin binding to its receptor TRPV1
Capsaicin binding to its receptor TRPV1
- Report rights infringement
- published: 09 Jun 2015
- views: 2181
3:09
GABA puts the brakes on TRPV1
Heidelberg University: At the Institute of Pharmacology, CellNetworks member Prof. Jan Sie...
published: 06 Sep 2016
GABA puts the brakes on TRPV1
GABA puts the brakes on TRPV1
- Report rights infringement
- published: 06 Sep 2016
- views: 679
7:25
Pore turret in TRPV1 heat activation - Cui et al.
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sen...
published: 26 Jul 2012
Pore turret in TRPV1 heat activation - Cui et al.
Pore turret in TRPV1 heat activation - Cui et al.
- Report rights infringement
- published: 26 Jul 2012
- views: 2460
0:33
Structure of Key Pain-Related Protein TRPV1 Unveiled
http://www.ucsf.edu/news/2013/12/110571/structure-key-pain-related-protein-unveiled
In a ...
published: 04 Dec 2013
Structure of Key Pain-Related Protein TRPV1 Unveiled
Structure of Key Pain-Related Protein TRPV1 Unveiled
- Report rights infringement
- published: 04 Dec 2013
- views: 4393
10:32
Proton-induced TRPV1 OFF response-Lee and Zheng
H+ not only activates the TRPV1 cation channel but inhibits ion permeation, yielding a pro...
published: 09 Nov 2015
Proton-induced TRPV1 OFF response-Lee and Zheng
Proton-induced TRPV1 OFF response-Lee and Zheng
- Report rights infringement
- published: 09 Nov 2015
- views: 328
12:17
Nociceptors - An Introduction to Pain
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www....
published: 13 Aug 2013
Nociceptors - An Introduction to Pain
Nociceptors - An Introduction to Pain
- Report rights infringement
- published: 13 Aug 2013
- views: 417397
0:33
TRPV1
published: 16 Dec 2015
TRPV1
TRPV1
- Report rights infringement
- published: 16 Dec 2015
- views: 163
4:28
Why Do Hot Peppers Cause Pain?
Subscribe! http://bit.ly/ACSReactions
You have probably had the burning sensation of eati...
published: 01 Dec 2015
Why Do Hot Peppers Cause Pain?
Why Do Hot Peppers Cause Pain?
- Report rights infringement
- published: 01 Dec 2015
- views: 219341
Pain and temperature | Integumentary system physio...
TRPV1 Ion channels...
Capsaicin binding to its receptor TRPV1...
GABA puts the brakes on TRPV1...
Pore turret in TRPV1 heat activation - Cui et al....
Structure of Key Pain-Related Protein TRPV1 Unveil...
Proton-induced TRPV1 OFF response-Lee and Zheng...
Nociceptors - An Introduction to Pain...
TRPV1...
Why Do Hot Peppers Cause Pain?...
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Unarmed Russian Air Force Jet Flies Over Pentagon, Capitol Under Open Skies Treaty
Edit WorldNews.com 10 Aug 2017
Two U.S. officials confirmed to The Washington Post a Russian surveillance plane flew through secure airspace over Washington on Wednesday, presumably collecting intelligence as it traveled near the Pentagon, the Capitol and other government buildings.Under terms of the Treaty on Open Skies – signed by Russia, the U.S ... and 3 p.m., the report said ... Capitol,” the Post reported.“This flight will be monitored by U.S ... Gen....
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Analysis: Poll Reveals Republican Voters Favor Trump Postponing 2020 Election
Edit WorldNews.com 10 Aug 2017
An analysis written by two professors published in The Washington Post Thursday questions how far Republicans would be willing to follow President Donald Trump’s lead to stop what they perceive as rampant voter fraud. About half of Republicans, the report said, would support postponing the 2020 presidential election until the country can fix this problem ... Again, this is similar to previous polls....
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Edit Yahoo Daily News 10 Aug 2017
By Idrees Ali. WASHINGTON (Reuters) - A U.S. Navy destroyer carried out a "freedom of navigation operation" on Thursday, coming within 12 nautical miles of an artificial island built up by China in the South China Sea, U.S. officials told Reuters ... The officials, speaking on condition of anonymity, said the USS John S. McCain traveled close to Mischief Reef in the Spratly Islands, among a string of islets, reefs and shoals ... U.S ... ....
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Edit Yahoo Daily News 10 Aug 2017
More. People wave banners and shout slogans as they attend a rally in support of North Korea's stance against the U.S., on Kim Il-Sung Square in Pyongyang on August 9. North Korea's military has accused President Donald Trump of warmongering and said it would act swiftly and decisively in the event of a war. KIM WON-JIN/AFP/Getty Images. North Korea has repeatedly claimed to have exposed what it calls U.S ... mainland." ... The U.S ... invasion ... U.S....
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Angelina Jolie and Brad Pitt rumoured to have called off their divorce
Edit Hindustan Times 10 Aug 2017
After filing for divorce in September 2016, Angelina Jolie is rumoured to have called off her divorce with husband Brad Pitt ... (AFP) ....
Flex Pharma Initiates ALS Phase 2 Trial with FLX-787 in US
Edit Market Watch 01 Aug 2017
BOSTON, Aug 01, 2017 (BUSINESS WIRE) -- Click to Tweet this News. Flex Pharma, Inc ... The COMMEND trial will evaluate FLX-787, the Company’s co-activator of TRPA1 and TRPV1, in patients with motor neuron disease (MND), focused on ALS, who suffer from painful, debilitating cramps. The FDA has granted FLX-787 Fast Track designation for the treatment of severe muscle cramps associated with ALS ... William McVicar, Flex Pharma President and CEO....
FDA Grants Fast Track Designation to Flex Pharma’s FLX-787 for the Treatment of Severe Muscle Cramps Associated with ALS
Edit Market Watch 25 Jul 2017
... diseases including amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Charcot-Marie-Tooth (CMT), today announced that the US Food and Drug Administration (FDA) has granted Fast Track designation for the development of FLX-787, the Company’s co-activator of TRPA1 and TRPV1, to treat severe muscle cramps in patients with ALS....
Why Chili Peppers and Spicy Foods Trigger Hiccups
Edit Mercola 22 Jul 2017
✓ Alcoholism ... Your body has transient receptor potential vanilloid 1 (TRPV1) pain receptors which are activated by capsaicin, opening the floodgates to pain ... After exposure, your TRPV1 receptors go through a period of rest ... The heat you’re feeling is the result of the activation of the TRPV1 receptors. Although the activation of TRPV1 helps to reduce pain, it may also be responsible for many of the other health benefits you experience....
Centrexion Therapeutics Provides Updates and Advancements for Pipeline of Chronic Pain Treatments
Edit Market Watch 18 Jul 2017
Stevens, M.D., chief medical officer of Centrexion Therapeutics ... CNTX-0290. Phase 1 Completed, Patent Awarded ... About CNTX-0290 ... CNTX-0290 works by activating the SSTR4 receptor, which functions as a “master control” switch to turn down the activity of several other pain receptors, such as specific calcium channels, potassium channels and TRPV1 and TRPA1 channels, thereby reducing the transmission of pain signals ... Additional Progress ... or....
Sorrento Therapeutics Announced FDA Authorization of IND to Commence Clinical Trial of RTX in Intractable Cancer Pain
Edit Market Watch 29 Jun 2017
Food and Drug Administration (FDA) has authorized the Company's Investigational New Drug Application (IND) for Resiniferatoxin (RTX), a non-opioid, TRPV1 agonist that selectively targets afferent nerve activation involved in chronic pain states ... When injected intrathecally, RTX has been shown to directly interact with nerve cells expressing TRPV1 ......
Radio-Controlled Genes Market Research Report: Forecast up to 2023
Edit Community news 23 Jun 2017
Genes are fundamental controlling structure in the living body, which contains all the information and hereditary data. It also contributes to the development, creation, and activity of all other cells ... View Report- ... The modified ion channel was temperature-sensitive ion channel known as TRPV1, a magnetic field was created with the help of hardware in a form of magnetic resonance imaging device to heat the nanoparticles ... North America....
Could this be the most bizarre cure for a dodgy tummy? Smoke cannabis while eating a curry to alleviate symptoms, research suggests
Edit This is Money 21 Jun 2017Sales of CBD-based Products Projected to Accelerate
Edit Market Watch 16 Jun 2017
in 2016 was $688 million ... ChineseInvestors.com, Inc ... MJNA, -1.43% ... The discoveries included a compound that is known to have a positive track record of safety in clinical trials and to provide pain relief through modulation of the vanilloid TRPV1 receptor. As a result, Vitality Biopharma has made broad patent claims covering use of CBD and other TRPV1 agonists for myelin repair and for treatment of demyelinating disorders ... Please Note....
GB Sciences Builds Broad Cannabis Patent Portfolio -- CFN Media
Edit Market Watch 16 Jun 2017
(otcqb.GBLX) and its drug development pipeline for novel cannabis-based therapies. Researchers have only scratched the surface of the medical value of cannabinoids as federal regulations are relaxed ... The company's therapeutics target the TRPV1 receptor that is protected under the approved patent that it licensed from Makai Biotechnology as of December 2016. Looking Ahead GB Sciences Inc ... Please follow the link to read the full article....
Centrexion Therapeutics Announces New 6-Month Data Demonstrating Significant and Durable Pain Relief with CNTX-4975 for Treatment of Moderate to Severe Knee Osteoarthritis Pain
Edit Market Watch 14 Jun 2017
The data are being presented in an invited presentation at the European League Against Rheumatism’s Annual European Congress of Rheumatology (EULAR 2017) in Madrid this week ... Stevens, M.D., chief medical officer of Centrexion Therapeutics ... Efficacy Endpoints Met At 24 Weeks ... from ... CNTX-4975 works by targeting the capsaicin receptor (TRPV1) to selectively and rapidly inactivate only the local pain fibers transmitting signals to the brain....
Centrexion Therapeutics Announces Oral Presentation of Six Month Efficacy Data on CNTX-4975 for the Treatment of Chronic Pain Associated with Knee Osteoarthritis at the Annual European Congress of Rheumatology (EULAR 2017)
Edit Market Watch 07 Jun 2017
Details of the oral presentation are listed below. Title (OPO167). Efficacy And Safety Of CNTX-4975 in Subjects with Moderate To Severe Osteoarthritis Knee Pain. 24-Week, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study. Session. Osteoarthritis ... Presentation Time ... CNTX-4975 works by selectively targeting the capsaicin receptor (TRPV1) to rapidly inactivate only the local pain fibers transmitting signals to the brain ... SOURCE....
Centrexion Therapeutics to Present Data on CNTX-4975 for the Treatment of Chronic Pain Associated with Knee Osteoarthritis at European Federation of National Associations of Orthopaedics and Traumatology’s 2017 Annual Congress
Edit Market Watch 25 May 2017
Details of the poster presentation, which was selected as one of the top 30 posters and was named a finalist for the Jacques Duparc Award by the EFORT Award Committee, are listed below. The poster will be available for viewing the duration of the congress. Abstract Title (#1202) ... CNTX-4975 works by selectively targeting the capsaicin receptor (TRPV1) to rapidly inactivate only the local pain fibers transmitting signals to the brain....
Radio-Controlled Genes Market Research Report : Forecast up to 2023
Edit Community news 25 May 2017
Genes are fundamental controlling structure in the living body, which contains all the information and hereditary data. It also contributes to the development, creation, and activity of all other cells ... View Report- ... The modified ion channel was temperature-sensitive ion channel known as TRPV1, a magnetic field was created with the help of hardware in a form of magnetic resonance imaging device to heat the nanoparticles ... North America....
GB Sciences Files Patent Application for Chronic Pain and Heart Therapies
Edit Market Watch 23 May 2017
The current provisional patent application covers myrcene-containing complex mixtures capable of targeting the non-traditional cannabinoid receptor, TRPV1. Our latest patent application complements the issued TRPV1 patent that GB Sciences licensed from Makai Biotechnology in December of 2016 ... Myrcene, like capsaicin, causes TRPV1 desensitization after prolonged exposure, and should therefore prove useful in treating chronic pain....
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