"Mr. Irrelevant" is the title bestowed each year upon the last pick of the annual National Football League draft. The first Mr. Irrelevant was Kelvin Kirk, pick number 487 of the 1976 draft. The current Mr. Irrelevant is quarterback Chandler Harnish of the Northern Illinois Huskies, who was selected by the Indianapolis Colts as pick number 253 of the 2012 draft.

"Irrelevant Week" arose in 1976, when former Southern California and NFL receiver Paul Salata founded the week in Newport Beach, California. He continues to announce the final pick of the NFL draft to this day. During the summer after the draft, the new Mr. Irrelevant and his family are invited to spend a week in Newport Beach, California, where they enjoy a golf tournament, a regatta, a roast giving advice to the new draftee, and a ceremony awarding him the Lowsman Trophy. The trophy mimics the Heisman, but depicts a player fumbling a football.

Several players who have been presented with this dubious honor have nevertheless succeeded in making the team that drafted them, with significant contributions on the field.

Mister, usually written in its abbreviated form Mr or Mr. (American English), is a commonly used English honorific for men under the rank of knighthood. The title derived from master, as the equivalent female titles, Mrs., Miss, and Ms, all derived from the archaic mistress. The title master was retained and used for boys and young men, but is now less commonly used. The plural form is Misters, or the abbreviation Messrs (UK) or Messrs. (US) ( /ˈmɛsərz/). This is an English abbreviation of the French "messieurs" (French pronunciation: [mesjø]), sometimes pronounced /ˈmɛsərz/ in English.

When addressing someone directly: Mr. is usually used with the last name only ("May I help you, Mr. Thompson?"). In other circumstances, it can be used with either the last name or the full name ("This is Mr. John Smith."; "Would you please help, Mr Smith?"). In formal written address, it is usually used along with the full name, or with initials and surname.

When a man's name is unknown, "mister" is sometimes used informally by itself in direct address, as in, "Hello, mister," or "Are you all right, mister?" rather than the standard form of address, "Sir". Though not necessarily meant disrespectfully, such use may to some people seem rude.