The A41 is a major trunk road in England that links London and Birkenhead, although it has now in parts been superseded by motorways. It passes through or near various towns and cities including Watford, Kings Langley, Hemel Hempstead, Aylesbury, Solihull, Birmingham, West Bromwich, Wolverhampton, Newport, Whitchurch, Chester and Ellesmere Port.

It follows part of the line of the old Roman road, Akeman Street and the eighteenth century Sparrows Herne turnpike.

With the opening of the M40 extension in 1990 linking with the M42 near Birmingham, much of the route was downgraded in importance - with the sections between Bicester and the M42 near Solihull being renumbered as the A4141, A4177 and B4100.

The route begins near Marble Arch in London, at the junction with Oxford Street (A40). Here, north-bound traffic uses Gloucester Place, the south-bound uses Baker Street. It becomes a dual-carriageway on Finchley Road, through Swiss Cottage, and along Hendon Way, and intersects with the North Circular Road near Brent Cross shopping centre. The road passes through Hendon and after the junction with the A5150, (close to the Metropolitan Police's police college and the RAF Museum), it runs directly next to the M1. The A41 overlaps the A1 at Five Ways Corner with the section known as Watford Way. It passes through Mill Hill, separating with the A1 at Apex Corner roundabout After crossing the M1, near Elstree, it links the M1 at Junction 4, and then meets the A5 at a roundabout (where the A5 becomes the A5183). The A41 continues next to the M1 into Hertfordshire. This section is known as Elton Way, as far as the roundabout with the B462. The next section is dual-carriageway.