Bone Thugs-N-Harmony is an American hip hop band from Cleveland, Ohio formed in 1991. It originally consisted of rappers Layzie Bone, Flesh-n-Bone, Bizzy Bone, Krayzie Bone, and Wish Bone. Rapper Eazy-E of the group N.W.A signed Bone Thugs-N-Harmony to Ruthless Records in late 1993, when Bone Thugs debuted with EP Creepin on ah Come Up. The EP included the hit single "Thuggish Ruggish Bone".

In 1995, the group released its second album, E. 1999 Eternal, which included hits "1st of tha Month" and "Tha Crossroads." A tribute to the recently deceased Eazy-E, "Tha Crossroads," won a Grammy award in 1997. The Art of War, the group's third album, was also released in 1997. Bone Thugs is also the only group that has worked with deceased artists 2Pac, The Notorious B.I.G., Eazy-E & Big Pun while they were still alive.

In 2000 BTNHResurrection reached platinum in one month and Thug World Order (2002) received more moderate sales and promotion. After the album the group went on hiatus and released their sixth studio album Thug Stories independently before returning in 2007 with the major label release Strength & Loyalty, this time released by Swizz Beatz's label Full Surface Records. Bone Thugs-n-Harmony officially returned with their new album Uni-5: The World's Enemy, released in 2010 by their own record label, BTNH Worldwide, with distribution by Warner Bros.. Due to internal conflicts with the group, longtime members Krayzie Bone and Wish Bone officially left the group in April 2011. Despite speculation that the group was splitting up, Flesh-n-Bone announced that a new album with him, Layzie and Bizzy will be released soon. Krayzie and Wish are currently working with upcoming artists on their label The Life Ent.

Bryon Anthony McCane II (born September 12, 1976), better known by his stage name Bizzy Bone, is an American rapper and the youngest member of the Cleveland rap group Bone Thugs-n-Harmony.

Bryon Anthony McCane was born to a half Native American and half African father and an Italian mother.^{[citation needed]} At the age of 5, Bryon and his two sisters were abducted by his stepfather. Both his sisters were natural children of Bryon's stepfather. He lived in many homes, apartments, cars and motels and was unaware at first that he had been abducted. He was told his mother had died. In 1983, he was living at a reservation in Oklahoma where his stepfather had dropped him off. A neighbor saw his photo at the end of the made-for-TV movie, Adam and called the police, resulting in his return to his family.

Thereafter, his childhood remained difficult. His mother remarried and Bryon's new stepfather physically abused him and his mother. Eventually, his mother divorced and put him and his sisters in a foster home until she could get her life back together.