- published: 11 Jul 2007
- views: 139945
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator. Substance P and its closely related neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:
with an amidation at the C-terminus. Substance P is released from the terminals of specific sensory nerves. It is found in the brain and spinal cord and is associated with inflammatory processes and pain. In 2014, the role of substance P to male aggression in fruit flies was identified.
The original discovery of Substance P (SP) was in 1931 by Ulf von Euler and John H. Gaddum as a tissue extract that caused intestinal contraction in vitro. Its tissue distribution and biologic actions were further investigated over the following decades. The eleven-amino-acid structure of the peptide was determined by Susan Leeman in 1971.
Will You may refer to:
Media Group (a.k.a. Indomedia group) is an Indonesian media group founded by Surya Paloh. The group owns three newspapers (the national Media Indonesia, and the regional Lampung Post and Borneonews), a tabloid Prioritas, and a television channel MetroTV.
Firelight Media is a non-profit filmmaking company founded by filmmaker Stanley Nelson and Marcia Smith, located in New York City. Firelight Media began in 1998 as an independent non-profit documentary production company that produced stories on topics that are typically underrepresented in the mainstream media, with most films airing nationally on PBS. In 2008, Firelight Media transitioned to focusing on supporting emerging filmmakers, while Firelight Films was launched as the new for-profit documentary production company led by Stanley Nelson.
The Producer’s Lab is the flagship program of Firelight Media. It is a yearly mentorship program that offers services to 15-20 emerging filmmakers to complete their films and gain national distribution. Participants receive consultation from Stanley Nelson, established producers, writers, editors, and fundraisers.
"Never Have I Ever", also known as "I've Never…" or "Ten Fingers", is a drinking game.
The verbal game is started with the players getting into a circle. Then, the first player says a simple statement starting with "Never have I ever". Anyone who has done what the first player has not must drink. Play then continues around the circle, and the next person makes a statement. An additional rule – uncommon, but beneficial to the game –is that if there is no one taking a drink, then the one who said the particular "I have never…" must take a drink. This rule often forces the players to strategize more and makes for less disposable/pointless suggestions.
A further variation holds that whenever only one person is drinking, that person must give a detailed account of why they are drinking. Another variation of this game involves putting up five or ten fingers, putting one down whenever something mentioned has been done. Those who end up putting down all of their fingers must take several successive drinks.
This animation represents the reaction that occurs when the nervous system is stimulated by pain. In the area of the synaptic clef neuro transmitters interact with receptor sites on the dendrite and dorsal root of the nerve cell. The electrical impules are created and nternalization occurs.
love is everything
Firelight Media Group worked with Wowhouse Pictures Inc. on these four medical animations. Wowhouse Medical (a division of Wowhouse Pictures) created 12 animations for their client. Firelight Media Group provided the sound design and mix. Russ Dube, Principal at Wowhouse, was looking for a way to present 4 of the 12 animations on the company's medical website. Byron Campbell, Principal at Firelight Media Group and Russ discussed what they could do to enhance the animations. Byron and Nick DeBeauvernet, the sound designer on the project from Firelight Media Group, worked together on the first animation to get the right feel. Once the feel was established Nick incorporated the sound design elements and mixed for the final animations. The voice over is provided by George Sarri...
Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P. Why you should listen – Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how...
Boost Metabolism and Reduce Pain with Cayenne Pepper!- Thomas DeLauer It's time for some real answers to why cayenne pepper can help you burn some fat! http://www.ThomasDeLauer.com Cayenne Pepper and Substance-P Effects on Inflammation and Brain: 1. For the past 9,000 years, Native Americans have employed cayenne pepper as both a food and medicine 2. Cayenne pepper has powerful pain-relieving properties when applied topically 3. The active ingredient in cayenne pepper is capsaicin 4. Capsaicin stimulates nerve endings so they release a receptor chemical, substance P, that transmits pain signals to the brain 5. When a nerve ending has released all of its substance P reserves, pain signals are no longer sent to the brain until substance P has been replenished 6. The result is pain relief f...
Real-Time Activation of a Mast Cell by Substance P: Photomicroscopy of one human mast cell placed between two cover slips and perfused with the neuropeptide substance P shows degranulation in real time as observed with the use of Nomarski (three-dimensional) optics. See the NEJM article, "Mast Cells, Mastocytosis, and Related Disorders".http://www.nejm.org/doi/full/10.1056/NEJMra1409760
La drogue et Alfouille ! Une longue histoire :D C'est partie pour toutes les games de placement, victoire comme défaite ! PS: Sachez que les VoD's on un décalage plus ou moins conséquent par rapport aux lives ! (Minimum 3 semaines peut s'étendre sur 2 mois) Par conséquent les vidéos ne représente ni le niveau actuel de jeux (au moment ou tu lis cette phrase) ni les découverte ! Bon visionnage :D PS2: Pour le bien de vous et moi même je met les commentaires en approuvé ! Pourquoi ? Parce que la plupart des petite haineux Platine et Diamant qui viennent parler alors qu'on les soulève In-Game c'est pas très Charlie. On a rien à prouver à personne, les vidéos sont faite pour passer du bon temps et prendre du fun avec un niveau pas forcément désagréable à regarder. Si Tu penses être une mach...
FREE Album DOWNLOAD: www.facebook.com/itchingMusic Facebook: www.facebook.com/itchingMusic Facebook: www.facebook.com/itchingBand Komposition: Nicolas David, Jan Montag, Gabriele Marchese Lyrics: [Scream] will you believe in me just the way you did before will you dig six feet deep to revive the good old times to revive I never thought I never thought a single day was worth the pain I'm going through was worth the pain that I created look in my eyes I'm going down for once and for all [Scream] and now I ask myself with every heartbeat I feel life I'm fucking dying now __________________________ Will you be there to hold my hand ? Will you be there to end my pain ? Will you be there when I hit the ground ? __________________________ I never found anything to live f...
As I struggle through a drunken maze
Here I climb the walls and stay up for days
Through my head speeds the chemical burn
Yes, I like it that way
My closest friends are powdered dreams
A bottomless glass, blackened smoke screen
My mind is sick but my arms are clean,
And I like it that way
Mt fucking life gets turned so upside down
At least it seems that way sometimes
The past two nights boy, have been the same fucked up day
A damn strange 48
My mind is sick
My soul is sick
My heart is sick
Just one more hour and I'll get some sleep
First do another shot to wash down the speed
How times flies as I'm killing myself
I wouldn't have no other way
Money slips through my trembling fingers
It's 6:00 am; I just bought more shit
The spots I see are like family
A damn strange 48
My mind is numb my blood runs thin
I've lost my grip but found religion
On a mirror lays my last future out
I can't go, oh God not this way
One final rush, as my life passes by
I can't stand up I don't feel quite right
I fade to black my soul deteriorates
That was my last?
48