Coordinates: 4°16′26″N 54°22′58″W / 4.2739°N 54.3828°W / 4.2739; -54.3828

Grand-Santi is a commune of French Guiana, an overseas region and department of France located in South America.

The commune was originally called Grand-Santi-Papaichton and included the now independent communes of Apatou and Papaichton. On 12 November 1976 Apatou was detached from Grand-Santi-Papaichton and became an independent commune. On 1 January 1993 Papaichton was also detached from Grand-Saint-Papaichton and became an independent commune. On that occasion, the name of the commune was shortened into Grand-Santi.

The Grand-Santi Airport is located 1 km (0.54 NM) northeast of Grand-Santi.

Santiago Santamaria i Puig (26 July 1957 – 16 February 2011), known as Santi Santamaria (Catalan pronunciation: [ˈsanti ˌsantəməˈɾi.ə]), was a prominent avant-garde Spanish Catalan chef. He was the first Catalan chef and owner to have his restaurant receive three stars from the Michelin Guide (Can Fabes in 1994).

His second restaurant, Sant Celoni, was awarded two Michelin stars.

His style was a modern interpretation of traditional Catalan cuisine and slow food, focusing on fresh Mediterranean ingredients.

Santamaria made controversial accusations against the "molecular gastronomy" of other Spanish chefs, singling out movement Ferran Adrià.

Santamaria died on 16 February 2011 in his restaurant in Marina Bay Sands, Singapore of a heart attack.