The Indianapolis 500-Mile Race, also known as the Indianapolis 500, the 500 Miles at Indianapolis, the Indy 500 or The 500, is held annually, typically on the last weekend in May (specifically over the Memorial Day weekend) at the Indianapolis Motor Speedway in Speedway, Indiana. The event lends its name to the IndyCar class, or formula, of open-wheel race cars that have competed in it.

The event, billed as The Greatest Spectacle in Racing, is considered one of the three most significant motorsports events in the world. The official attendance is not disclosed by Speedway management, but the permanent seating capacity is more than 257,000 people, and infield seating raises capacity to an approximate 400,000.

The Indianapolis 500 is held annually at the Indianapolis Motor Speedway, a 2.5 mile oval circuit. The race consists of 200 laps, run counterclockwise around the circuit, for a distance of 500 miles.

Traditionally, the field consists of 33 starters, aligned in a starting grid of eleven rows of three cars apiece. The event is contested by "Indy cars", a formula of professional-level, single-seat, open cockpit, open-wheel, purpose-built race cars. As of 2012, all entrants utilize 2.2 L V6 turbocharged engines, tuned to produce a range of 550–700 horsepower (410–520 kW).

Indianapolis  /ˌɪndiəˈnæpɵlɨs/ (abbreviated Indy /ˈɪndi/) is the capital of the US state of Indiana, and the county seat of Marion County, Indiana. As of the 2010 United States Census, the city's population is 829,718. It is Indiana's largest city and, as of the 2010 U.S. Census, is the 12th largest city in the U.S., the second largest city in the Midwest (behind Chicago), the second most populous state capital (after Phoenix, Arizona), and the most populous state capital east of the Mississippi River. Indianapolis is also one of the fastest growing regions in the United States.

For much of its history, Indianapolis has oriented itself around government and industry, particularly manufacturing. Today, Indianapolis has a much more diversified economy, contributing to the fields of education, health care, and finance. Tourism is also a vital part of the economy of Indianapolis, and the city plays host to numerous conventions and sporting events. Of these, perhaps the most well known is the annual Indianapolis 500 and the NHRA U.S. Nationals. Other major sporting events include the Brickyard 400 and the Men's and Women's NCAA Basketball Tournaments. 2012 marked the first time Indianapolis hosted the Super Bowl. Super Bowl XLVI was played at Lucas Oil Stadium, on February 5, 2012 in Downtown Indianapolis. Also held in Lucas Oil Stadium is the Drum Corps International World Championships, and the Music for All Bands of America Grand National Championships.