An entheogen ("generating the divine within") is a psychoactive substance used in a religious, shamanic, or spiritual context. With the advent of organic chemistry, there now exist many synthetic substances with similar psychoactive properties, many derived from these plants. Entheogens can supplement many diverse practices for healing, transcendence, and revelation, including: meditation, psychonautics, art projects, and psychedelic therapy.

Entheogens have been used in a ritualized context for thousands of years; their religious significance is well established in anthropological and modern evidences. Examples of traditional entheogens include: kykeon, ambrosia, iboga, peyote, bufotenine, ayahuasca, and datura. Other traditional entheogens include cannabis, ethanol, ergine, psilocybe mushrooms, and opium. Many pure active compounds with psychoactive properties have been isolated from organisms and chemically synthesized, including mescaline, psilocin/psilocybin, DMT, salvinorin A, ibogaine, and scopolamine. Semi-synthetic (e.g. LSD derived from LSA) and synthetic substances (e.g. DPT used by the Temple of the True Inner Light and 2C-B used by the Sangoma) have also been developed. Entheogens may be compounded through the work of a shaman or apothecary in a tea, admixture, or potion like ayahuasca or bhang.

William Melvin "Bill" Hicks (December 16, 1961 – February 26, 1994) was an American stand-up comedian, social critic, satirist, and musician. His material largely consisted of general discussions about society, religion, politics, philosophy, and personal issues. Hicks' material was often controversial and steeped in dark comedy. In both his stand-up performances and during interviews, he often criticized consumerism, superficiality, mediocrity, and banality within the media and popular culture, describing them as oppressive tools of the ruling class, meant to "keep people stupid and apathetic".

Hicks was 16 years old when he started performing stand-up comedy at the Comedy Workshop in Houston, Texas, in 1978. During the 1980s he toured the United States extensively and performed a number of high profile television appearances. It was in the UK, however, where Hicks first amassed a significant fan base, packing large venues with his 1991 tour. Hicks died of pancreatic cancer in 1994 at the age of 32. In the years after his death, his work and legacy achieved acclaim in creative circles. In 2007 he was voted the fourth-greatest stand-up comic on the UK's 100 Greatest Stand-Ups on Channel 4, and appeared again in the updated 2010 list as the fourth-greatest comic.