Coordinates: 38°51′N 35°38′E / 38.85°N 35.633°E / 38.85; 35.633 Kültepe (Turkish: Ash Hill) is a modern village near the ancient city of Kaneš or Kanesh (Hittite: Neša, occasionally Anisa), located in the Kayseri Province of Turkey's Central Anatolia Region. The nearest modern city to Kültepe is Kayseri, about 20 km southwest.

Kaneš, inhabited continuously from the Chalcolithic period to Roman times, flourished as an important Hattic/Hittite/Hurrian city, which contained a large merchant quarter (kârum) of the Old Assyrian kingdom, from ca. 20th to 16th centuries BC. A late (c 1400 BC) witness to an old tradition includes a king of Kaneš called Zipani among seventeen local city-kings who rose up against the Akkadian Naram-Sin (ruled c.2254-2218 BC). It is the site of discovery of the earliest traces of the Hittite language, and the earliest attestation of any Indo-European language, dated to the 20th century BC. The native term for the Hittite language was nešili "language of Neša".

The king of Zalpuwa, Uhna, raided Kanes, after which the Zalpuwans carried off the city's "Sius" idol. Pithana, the king of Kussara, conquered level Ia Neša "in the night, by force", but "did not do evil to anyone in it." Neša revolted against the rule of Pithana's son, Anitta, but Anitta quashed the revolt and made Neša his capital. Anitta further invaded Zalpuwa, captured its king Huzziya, and recovered the Sius idol for Neša.