Kuzhithurai (Tamil: குழித்துறை) is a city and a municipality in Kanniyakumari District in the Indian state of Tamil Nadu. It is the administrative headquarters of the Vilavancode Taluk. It has a historical seaport (thurai) where ancient merchants came from across the Arabian sea in ancient times. It is mentioned in ancient Indian maps.

As of 2001^[update] India census, Kuzhithurai had a population of 20,326. Males constitute 49% of the population and females 51%. Kuzhithurai has an average literacy rate of 82%, higher than the national average of 59.5%: male literacy is 84%, and female literacy is 80%. In Kuzhithurai, 10% of the population is under 6 years of age.

Kuzhithurai municipality spreads over an area of 5 km². The Thamiraparani river flows through Kuzhithurai.

This town is now famous for the annual Vavu Bali ancestor worship ceremony that is held here during Karkidaka vavu in July. The pooja festival here was also made popular with an exhibition founded by Shri. T.C Kesava Pillai, MLC, MLA, and the first muncipal chairman in the early 1900s, with lots of festivities and entertainment. Thousands of people from Kerala and Tamil Nadu visit this area for pithru bali tharpanam and exhibition every year. Vavu means - black (new) moon and Bhali means - Dedication/prayers to the souls of the dead/departed ones. This annual Bali to respect the ancestors is observed with flowers and rice on the bank of the river Thamaraparani of Kuzhithurai.