Marsilio Ficino (Latin name: Marsilius Ficinus) (Italian pronunciation: [marˈsiljo fiˈtʃino]; October 19, 1433 – October 1, 1499) was one of the most influential humanist philosophers of the early Italian Renaissance, an astrologer, a reviver of Neoplatonism who was in touch with every major academic thinker and writer of his day, and the first translator of Plato's complete extant works into Latin. His Florentine Academy, an attempt to revive Plato's school, had enormous influence on the direction and tenor of the Italian Renaissance and the development of European philosophy.

Ficino was born at Figline Valdarno. His father was a physician under the patronage of Cosimo de' Medici, who took the young man into his household and became the lifelong patron of Marsilio, who was made tutor to his grandson, Lorenzo de' Medici. Giovanni Pico della Mirandola, the Italian humanist philosopher and scholar was another of his students.

During the sessions at Florence of the Council of Ferrara-Florence in 1438–1445, during the failed attempts to heal the schism of the Orthodox and Catholic churches, Cosimo de' Medici and his intellectual circle had made acquaintance with the Neoplatonic philosopher George Gemistos Plethon, whose discourses upon Plato and the Alexandrian mystics so fascinated the learned society of Florence that they named him the second Plato. In 1459 John Argyropoulos was lecturing on Greek language and literature at Florence, and Ficino became his pupil.

Lorenzo de' Medici (1 January 1449 – 9 April 1492) was an Italian statesman and de facto ruler of the Florentine Republic during the Italian Renaissance. Known as Lorenzo the Magnificent (Lorenzo il Magnifico) by contemporary Florentines, he was a diplomat, politician and patron of scholars, artists, and poets. Perhaps what he is most known for is his contribution to the art world, giving large amounts of money to artists so they may create master works of art. His life coincided with the high point of the early Italian Renaissance; his death marked the end of the Golden Age of Florence. The fragile peace he helped maintain between the various Italian states collapsed with his death. Lorenzo de' Medici is buried in the Medici Chapel in Florence.

Lorenzo's grandfather, Cosimo de' Medici, was the first member of the Medici family to combine running the Medici bank with leading the Republic. Cosimo, one of the wealthiest men in Europe, spent a very large portion of his fortune in government and philanthropy. He was a patron of the arts and funded public works. Lorenzo's father, Piero 'the Gouty' de' Medici, was also at the center of Florentine life, active as an art patron and collector. His mother Lucrezia Tornabuoni was a poet and writer of sonnets. She was also a friend to figures such as Luigi Pulci and Agnolo Poliziano and became her son's advisor when he took over power.