An intercity bus is a bus that carries passengers significant distances between different cities, towns, or other populated areas. Unlike a municipal bus, which has frequent stops throughout a city or town, an intercity bus generally has a single stop at a centralized location within the city, and travels long distances without stopping at all. Intercity buses exist all over the world that are operated by government or private industry, for profit and not for profit.

While also serving heavily populated urban areas, intercity bus services are of prime importance in lightly populated rural areas that often have little or no public transportation.

Intercity buses are one of four common transport methods between cities, not all of which are available in all places. The others are airplane, train, and private automobile. In the United States in 1997, intercity bus transportation accounted for 3.6% of all miles traveled between these four modes.

Intercity buses, as they hold passengers for significant periods of time, are designed to meet these needs. Some characteristics include: