C. B. Fisk

C.B. Fisk, Inc. is a company in Gloucester in the U.S. state of Massachusetts that designs and builds mechanical action pipe organs. It was founded in 1961 by Charles Brenton Fisk (1925–1983), the first American organ builder to build significant tracker organs in the 20th century. His study of early American and European instruments led him to return to mechanical action and to set a new course for American organ building. He modeled his shop on collaborative enterprise, launching the careers of four other North American organ builders and providing the foundation for those who carry on the company he founded.

About Charles Brenton Fisk

Born in Washington, D.C., and raised in Cambridge, Massachusetts, Fisk loved music and grew up tinkering with hifi equipment. He was a chorister at Christ Church on Cambridge Common where E. Power Biggs was Choirmaster. Charles showed such intelligence as a young man that when he was drafted during WWII, he was sent to Los Alamos where he worked for Robert Oppenheimer on the Manhattan Project. He was 18 years old. After the war he attended Harvard and Stanford, majoring in nuclear physics, and worked briefly at Brookhaven National Laboratories, but during his Stanford years decided to pursue a career in organ building.

Caught

Caught is a method of dismissing a batsman in the sport of cricket. Being caught out is the most common method of dismissal at higher levels of competition. This method of dismissal is covered by Law 32 of the Laws of cricket which reads:

A batsman is out caught if a fielder catches the ball fully within the field of play without it bouncing once the ball has touched the striker's bat or glove holding the bat. If a batsman could be given out caught or by any other method except bowled, 'caught' takes precedence.

This means that the batsman cannot be out caught if:

3C 66B

3C 66B is an elliptical Fanaroff and Riley class 1 radio galaxy located in the constellation Andromeda. With an estimated redshift of 0.021258, the galaxy is about 300 million light-years away.

The orbital motion of 3C 66B showed supposed evidence for a supermassive black hole binary (SMBHB) with a period of 1.05 ± 0.03 years, but this claim was later proven wrong (at 95% certainty).

Messier 87 (M87), about 55 million light years away, is the largest giant elliptical galaxy near the Earth, and also contains an active galactic nucleus. The smooth jet of 3C 66B rivals that of M87.

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Complement membrane attack complex

The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the cell membrane of target cells, leading to cell lysis and death.

A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9.

Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}.

Structure and function

It is composed of a complex of four complement proteins (C5b, C6, C7, and C8) that bind to the outer surface of the plasma membrane, and many copies of a fifth protein (C9) that hook up to one another, forming a ring in the membrane. C6-C9 all contain a common MACPF domain. This region is homologous to cholesterol-dependent cytolysins from Gram-positive bacteria.