The inline-four engine or straight-four engine is an internal combustion engine with all four cylinders mounted in a straight line, or plane along the crankcase. The single bank of cylinders may be oriented in either a vertical or an inclined plane with all the pistons driving a common crankshaft. Where it is inclined, it is sometimes called a slant-four. In a specification chart or when an abbreviation is used, an inline-four engine is listed either as I4 or L4 (for longitudinal, to avoid confusion between the digit 1 and the letter I).

The inline-four layout is in perfect primary balance and confers a degree of mechanical simplicity which makes it popular for economy cars. However, despite its simplicity, it suffers from a secondary imbalance which causes minor vibrations in smaller engines. These vibrations become worse as engine size and power increase, so the more powerful engines used in larger cars generally are more complex designs with more than four cylinders.

Today almost all manufacturers of four-cylinder engines for automobiles produce the inline-four layout, with Subaru's Flat-four engine being a notable exception, and so four-cylinder is synonymous with and a more widely used term than inline-four. The inline-four is the most common engine configuration in modern cars, while the V6 engine is the second most popular. In the late 2000s, with auto manufacturers making efforts to reduce emissions; and increase fuel efficiency due to the high price of oil and the economic recession, the proportion of new vehicles sold in the U.S. with four-cylinder engines (largely of the inline-four type) rose from 30 percent to 47 percent between 2005 and 2008, particularly in mid-size vehicles where a decreasing number of buyers have chosen the V6 performance option.