San Leucio is a frazione of the comune of Caserta, in the region of Campania in southern Italy. It is most notable for a resort developed around an old silk factory, included in the UNESCO World Heritage sites list in 1997.

It is located 3.5 km northwest of Caserta, at 145 m above sea level.

In 1750 Charles VII of Naples, advised by minister Bernardo Tanucci, selected this place, originally the site of a royal hunting lodge for the Acquaviva family (now restored, and known as Palazzo del Belvedere), for an unusual social and tecnological experiment, a different model of production based on technical innovation and alert to the needs of workers. In its early days, San Leucio resort was a place for pleasure and a royal hunting preserve, built on the ruins of Saint Leucio church, where an aqueduct carried water to the waterfalls of the Royal Caserta Palace, designed by Vanvitelli. The son of Charles, Ferdinand I, had a hunting lodge built for himself on this site. He was a very skillful hunter who disliked the pleasures and luxury of court life. It was here that Charles and the young king Ferdinand built a silk factory. The complex was transformed into a silk production site and industrial buildings were added, which was quite unique in late 18th-century Europe. Architect Francesco Collecini designed these industrial buildings, where noisy looms were installed next to royal apartments and a sitting room became a chapel for the workers.