Mayo Clinic is a not-for-profit medical practice and medical research group based in Rochester, Minnesota, specializing in treating difficult cases (tertiary care). Patients are referred to Mayo Clinic from across the U.S. and the world, and it is known for innovative and effective treatments. Mayo Clinic is known for being at the top of most accredited quality standard listings; for example, it has been near the top of the U.S. News & World Report List of Best Hospitals for more than 20 years. The practice is distinguished by integrated care, and a strong research presence is evidenced by the fact that over 40% of its resources are devoted towards research (rather than just medical practice).

Mayo Clinic has been on the list of America's "100 Best Companies to Work For" published by Fortune magazine for eight years in a row. From its humble beginnings as a family venture between a father and his two sons, the practice later became America's first integrated group practice, a model that is now standard in the United States. The current-day Mayo Clinic is an integrated practice of more than 3,700 physicians and scientists, and a total employment including nurses, students, and allied health staff of more than 56,000 persons.

Hunter Doherty "Patch" Adams (born May 28, 1945, in Washington, D.C.) is an American physician, social activist, citizen diplomat and author. He founded the Gesundheit! Institute in 1971. Each year he organizes a group of volunteers from around the world to travel to various countries where they dress as clowns in an effort to bring humor to orphans, patients, and other people.

Adams is currently based in Urbana, Illinois. In collaboration with the institute, he promotes an alternative health care model, not funded by insurance policies.

Adams had a difficult childhood. His father, an officer in the United States Army, had fought in Korea, and died while stationed in Germany when Adams was still a teenager. After his father's death, Adams returned to the United States with his mother and brother. Upon his return, Adams has stated that he encountered institutional injustice which made him a target for bullies at school. As a result, Adams was unhappy and became actively suicidal. After being hospitalized three times in one year for wanting to end his life, he decided "you don't kill yourself; you make revolution."^{[citation needed]}