The 2007 NFL season was the 88th regular season of the National Football League.

Regular-season play was held from September 6 to December 30.

The New England Patriots became the first team to complete the regular season undefeated since the league expanded to a 16-game regular season in 1978. Four weeks after the playoffs began on January 5, 2008, the Patriots lost to the New York Giants in Super Bowl XLII, the league championship game at University of Phoenix Stadium in Glendale, Arizona on February 3, by a score of 17–14.

The Hall of Fame Game was played in Canton, Ohio on Sunday August 5, 2007, with the Pittsburgh Steelers defeating the Saints by a score of 20–7; the game was televised by the NFL Network, replacing NBC, who had been previously scheduled to broadcast the China Bowl exhibition game from Beijing, China on August 8, 2007 between the New England Patriots and the Seattle Seahawks at Workers Stadium. However, with all efforts being put into the London regular season game, plans for the game were postponed, as Beijing hosted the 2008 Summer Olympics.

The National Football League has enjoyed success in selling out many of their venues from season ticket sales alone. Out of 32 teams in the league, 24 claim to have waiting lists from under 1,000 people to over 150,000. For some fans, this means a wait not just of years, but decades. This is due mostly to the NFL's short window of play; there are only eight regular-season home games, forcing the most devoted fans into a desperate and sometimes costly search for a limited number of events.

Since 1973, the waiting lists have also had the by-product of preventing any home games of certain teams from being blacked out on local television. Home games must be sold out within 72 hours of kickoff before a telecast is allowed, and the longest waiting lists have ensured every home game of the applicable teams being locally televised. Prior to 1973, home games could not be locally televised even if they were sold out. Four teams have had the benefit of not seeing any blackouts at all since 1972.

Personal Seat Licenses (PSLs) is a license which grants the holder the right to buy season tickets for a particular team. PSLs were first used in the NFL by the expansion Carolina Panthers in 1993 to help finance their new stadium. Since that time, several teams have used the mechanism to finance new stadium projects including the Chicago Bears remodel of Soldier Field and more recently the Dallas Cowboys. The New York Jets and the New York Giants used PSL programs to finance the construction of the New Meadowlands Stadium, now MetLife Stadium.