"Super AIDS" is a general term describing potentially more deadly mutants of the human immunodeficiency virus. The phrase "Super AIDS" is used informally in discussion and entertainment, such as the South Park episode The Death of Eric Cartman.

Some reports have used the term "super AIDS" regarding multidrug resistant strains of HIV-1 (MDR HIV-1) found in New York City in 2005. The initial case was described by New York City Health Commissioner Thomas Frieden as holding "the potential for a very serious public health problem", and by Ronald Valdiserri, deputy director of the National Center for HIV, as "quite alarming", though the strain retained vulnerability to enfuvirtide. During a subsequent thirteen-month study in New York City, laboratories genotyping HIV to predict drug resistance were asked to report all genotypes resistant to more than three nucleoside/nucleotide analogue reverse transcriptase inhibitors, or any non-nucleoside reverse transcriptase inhibitor, or more than three protease inhibitors. The resulting data, from 189 persons, indicated a low prevalence of multidrug resistance in newly infected persons, but led to funding for further studies. In 2006, provisional data indicated that 15% of new infections were resistant to one antiretroviral drug, and 3.2% to two such drugs. As a result the U.S. Department of Health and Human Services changed its guidelines to recommend testing for drug resistance before beginning antiretroviral treatment in new patients.

Rucka Rucka Ali is an American rapper, radio personality, singer, comedian, and satirist most noted for his song parodies on YouTube. He has been labelled one of the most successful artists to come out of YouTube, where he has received over 100 million hits with hits such as "Ching Chang Chong" and "Justin's Beaver". He released several albums, two of which charted in the Billboard Top Comedy Albums. In 2009, he launched his own label, Pinegrove Records.

Most of Rucka Rucka Ali's music are parodies. His hits include "Ching Chang Chong", a parody of The Black Eyed Peas' "Boom Boom Pow" full of Asian stereotypes and "Justin's Beaver", a parody of B.o.B's "Magic" ridiculing Justin Bieber. Rucka Rucka Ali released several albums, two of which charted in the Billboard Top Comedy Albums, I'm Black, You're White & These Are Clearly Parodies which peaked at No. 6 and Probably Racist which peaked at No. 11.