The United States Secretary of State is the head of the United States Department of State, concerned with foreign affairs. The Secretary is a member of the Cabinet and the highest-ranking cabinet secretary both in line of succession and order of precedence. The current Secretary of State is Hillary Rodham Clinton, the 67th person, and third woman to hold the post. The specific duties of the Secretary of State include:

The original duties of the Secretary of State include some domestic duties, such as:

Most of the domestic functions of the Department of State have been transferred to other agencies. Those that remain include storage and use of the Great Seal of the United States, performance of protocol functions for the White House, and the drafting of certain proclamations. The Secretary also negotiates with the individual States over the extradition of fugitives to foreign countries.President Nixon's resignation, a domestic issue, was also addressed to the Secretary of State.

As the highest-ranking member of the cabinet, the Secretary of State is the third-highest official of the executive branch of the Federal Government of the United States, after the President and Vice President and is fourth in line to succeed the Presidency, coming after the Vice President, the Speaker of the House of Representatives, and the President pro tempore of the Senate. Six Secretaries of State have gone on to be elected President.

Secretary of State or State Secretary is a commonly used title for a senior or mid-level post in governments around the world. The role varies between countries, and in some cases there are multiple Secretaries of State in the Government.

In many countries, a Secretary of State is a mid-level post. It is usually a politically appointed position, although in some countries, such as Germany and Sweden, it can be filled by a member of the executive bureaucracy (civil service) as a political appointment. In the Holy See, there is one Secretary of State, who coordinates all the departments of the Roman Curia (that is, equivalent to a Prime Minister). In the United Kingdom a Secretary of State is a member of the Cabinet appointed by the Queen on the advice of the Prime Minister (that is, equivalent to a Minister). In the federal government of the United States of America, there is one Secretary of State, the most senior political appointee responsible for foreign policy (that is, equivalent to a Foreign Minister).

John Forbes Kerry (born December 11, 1943) is the senior United States Senator from Massachusetts, the 10th most senior United States Senator and chairman of the Senate Foreign Relations Committee. He was the presidential nominee of the Democratic Party in the 2004 presidential election, but lost to then President George W. Bush.

The son of an Army Air Corps serviceman, Kerry was born in Aurora, Colorado. He attended boarding school in Massachusetts and New Hampshire and went on to graduate from Yale University class of 1966, where he majored in political science. He enlisted in the Naval Reserve in 1966 and, during 1968-1969, served a four-month tour of duty in South Vietnam as officer-in-charge (OIC) of a Swift Boat. For that service he was awarded several combat medals that include the Silver Star, Bronze Star, and three Purple Hearts. After returning to the United States, Kerry joined the Vietnam Veterans Against the War in which he served as a nationally recognized spokesperson and as an outspoken opponent of the Vietnam war. During that period, he appeared before the Senate Committee on Foreign Affairs where he deemed United States war policy in Vietnam to be the cause of "war crimes".

Joseph Robinette "Joe" Biden, Jr. (pronunciation: /ˈdʒoʊsɨf rɒbɨˈnɛt ˈbaɪdən/; born November 20, 1942) is the 47th and current Vice President of the United States, serving under President Barack Obama. A Democrat, he was a United States Senator from Delaware from January 3, 1973 until his resignation on January 15, 2009, following his election to the Vice Presidency.

Biden was born in Scranton, Pennsylvania and lived there for ten years before moving to Delaware. He became an attorney in 1969, and was elected to a county council in 1970. Biden was first elected to the Senate in 1972 and became the sixth-youngest senator in U.S. history. He was re-elected to the Senate six times, was the fourth most senior senator at the time of his resignation, and is the 15th-longest serving Senator in history. Biden was a long-time member and former chairman of the Foreign Relations Committee. His strong advocacy helped bring about U.S. military assistance and intervention during the Bosnian War. He opposed the Gulf War in 1991. He voted in favor of the Iraq War Resolution in 2002, but later proposed resolutions to alter U.S. strategy there. He has also served as chairman of the Senate Judiciary Committee, dealing with issues related to drug policy, crime prevention, and civil liberties, and led creation of the Violent Crime Control and Law Enforcement Act and Violence Against Women Act. He chaired the Judiciary Committee during the contentious U.S. Supreme Court nominations of Robert Bork and Clarence Thomas.

Condoleezza Rice ( /ˌkɒndəˈliːzə/; born November 14, 1954) is an American political scientist and diplomat. She served as the 66th United States Secretary of State, and was the second person to hold that office in the administration of President George W. Bush. Rice was the first female African-American secretary of state, as well as the second African American (after Colin Powell), and the second woman (after Madeleine Albright). Rice was President Bush's National Security Advisor during his first term, making her the first woman to serve in that position. Before joining the Bush administration, she was a professor of political science at Stanford University where she served as Provost from 1993 to 1999. Rice also served on the National Security Council as the Soviet and East European Affairs Advisor to President George H.W. Bush during the dissolution of the Soviet Union and German reunification.

Following her confirmation as Secretary of State, Rice pioneered the policy of Transformational Diplomacy, with a focus on democracy in the Greater Middle East. Her emphasis on supporting democratically elected governments faced challenges as Hamas captured a popular majority in Palestinian elections, and influential countries including Saudi Arabia and Egypt maintained authoritarian systems with U.S. support. While Secretary of State, she chaired the Millennium Challenge Corporation's board of directors.