Year 1566 (MDLXVI) was a common year starting on Tuesday (link will display the full calendar) of the Julian calendar.

Pieter Bruegel (Brueghel) the Elder (Dutch pronunciation: [ˈpitəɾ ˈbɾøːɣəl]; c. 1525 – 9 September 1569) was a Flemish Renaissance painter and printmaker known for his landscapes and peasant scenes (so called genre painting). He is sometimes referred to as the "Peasant Bruegel" to distinguish him from other members of the Brueghel dynasty, but he is also the one generally meant when the context does not make clear which Brueghel is being referred to. From 1559 he dropped the 'h' from his name and signed his paintings as Bruegel.

According to some sources he was born in Breugel near the (now Dutch) town of Breda. There are however also records that he was born in Breda, and there is some uncertainty whether the (now Belgian) town of Bree, called Breda in Latin, is meant. He was an apprentice of Pieter Coecke van Aelst, whose daughter Mayken he later married. He spent some time in France and Italy, and then went to Antwerp, where in 1551 he was accepted as a master in the painter's guild. He traveled to Italy soon after, and then returned to Antwerp before settling in Brussels permanently 10 years later.

Giuseppe Arcimboldo (Italian pronunciation: [dʒuˈzɛppe artʃimˈbɔldo]; also spelled Arcimboldi) (1527 – July 11, 1593) was an Italian painter best known for creating imaginative portrait heads made entirely of such objects as fruits, vegetables, flowers, fish, and books – that is, he painted representations of these objects on the canvas arranged in such a way that the whole collection of objects formed a recognizable likeness of the portrait subject.

His father, Biagio Arcimboldo, was an artist. Like his father, Giuseppe Arcimboldo started his career as a designer for stained glasses and frescoes at local cathedrals when he was 21 years old.

In 1562 he became court portraitist to Ferdinand I at the Habsburg court in Vienna, and later, to Maximilian II and his son Rudolf II at the court in Prague. He was also the court decorator and costume designer. King Augustus of Saxony, who visited Vienna in 1570 and 1573, saw Arcimboldo's work and commissioned a copy of his "The Four Seasons" which incorporates his own monarchic symbols.

Amati is the name of a family of Italian violin makers, who flourished at Cremona from about 1549 to 1740.

Andrea Amati (ca. 1505 – ca. 1578) was the earliest maker of violins whose instruments still survive today. Indeed he seems more or less responsible together with Gasparo da Salò and some Micheli's like Zanetto or Pellegrino for giving the instruments of the modern violin family their definitive profile. A very small number of his instruments survive, dated between the years of 1560 and 1574 and most bearing the coat of arms of Charles IX of France. His work is marked by great elegance and an awareness of geometrical principles in design.

Andrea Amati was succeeded by his sons Antonio Amati (born ca. 1550) and Girolamo Amati (1551–1635). "The Brothers Amati", as they were known, implemented far-reaching innovations in design, including the perfection of the shape of the f-holes. They are also thought to have pioneered the modern alto format of viola, in contrast to older tenor violas, but this stating is not correct since Gasparo made violas from altos of 39 to tenors of 44,7 cm.

Antonio de Cabezón (30 March 1510 – 26 March 1566) was a Spanish Renaissance composer and organist. Blind from childhood, he quickly rose to prominence as performer and was eventually employed by the royal family. He was among the most important composers of his time and the first major Iberian keyboard composer.

Cabezón was born in Castrillo Matajudíos, a municipality near Burgos, in the north of Spain. Nothing is known about his formative years. He became blind in early childhood, and he may have been educated at the Palencia Cathedral by the organist there, García de Baeza. At the time, the country was slowly entering its Golden Age. On 14 March 1516 Charles V was proclaimed King of Castile and of Aragon jointly with his mother, the first time the crowns of Castile and Aragon were united under the same king. After the death of his paternal grandfather, Maximilian, in 1519, Charles also inherited the Habsburg lands in Austria, and later went on to become Emperor of the Holy Roman Empire and one of the most powerful monarchs in the world.