In nuclear physics and nuclear chemistry, nuclear fission refers to either a nuclear reaction or a radioactive decay process in which the nucleus of an atom splits into smaller parts (lighter nuclei), often producing free neutrons and photons (in the form of gamma rays), and releasing a very large amount of energy, even by the energetic standards of radioactive decay. The two nuclei produced are most often of comparable but slightly different sizes, typically with a mass ratio of products of about 3 to 2, for common fissile isotopes. Most fissions are binary fissions (producing two charged fragments), but occasionally (2 to 4 times per 1000 events), three positively charged fragments are produced, in a ternary fission. The smallest of these fragments in ternary processes ranges in size from a proton to an argon nucleus.

Fission as encountered in the modern world is usually a deliberately-produced manmade nuclear reaction induced by a neutron. It is less commonly encountered as a natural form of spontaneous radioactive decay (not requiring a neutron), occurring especially in very high-mass-number isotopes. The unpredictable composition of the products (which vary in a broad probabilistic and somewhat chaotic manner) distinguishes fission from purely quantum-tunnelling processes such as proton emission, alpha decay and cluster decay, which give the same products each time.