The 1945 World Series matched the American League Detroit Tigers against the National League Chicago Cubs. The Tigers won the Series, four games to three, giving them their second championship and first since 1935.

Paul Richards picked up four runs batted in in the seventh game of the series, to lead the Tigers to the 9–3 game win, and 4–3 Series win.

The World Series again used the 3–4 wartime setup for home field sites, instead of the normal 2–3–2. Although the major hostilities of World War II had ended, some of the rules were still in effect. Many of the majors' better players were still in military service. Warren Brown, author of a history of the Cubs in 1946, commented on this by titling one chapter "World's Worst Series". He also cited a famous quote of his, referencing himself anonymously and in the third person. When asked who he liked in the Series, he answered, "I don't think either one of them can win it."

In a similar vein, Frank Graham jokingly called this Series "the fat men versus the tall men at the office picnic."

The World Series is the annual championship series of Major League Baseball (MLB), played between the American League and National League champions since 1903. The winner of the World Series championship is determined through a best-of-seven playoff and awarded the Commissioner's Trophy. As the series is played in October, Major League Baseball also refers to it as the "Fall Classic". The most recent World Series was won by the St. Louis Cardinals, who defeated the Texas Rangers in 7 games in 2011.

The New York Yankees of the American League have played in 40 World Series and won 27, and the Oakland/Philadelphia Athletics have played in 14 and won 9. In the National League, the St. Louis Cardinals have played in 18 and won 11, while the San Francisco/New York Giants and Los Angeles/Brooklyn Dodgers have both appeared in 18 and won 6.

Until the formation of the American Association in 1882 as a second major league, the National Association of Professional Base Ball Players (1871–75) and then the National League (founded 1876) represented the top level of organized baseball in the United States. All championships went to whoever had the best record at the end of the season, without a postseason series being played. Starting in 1884 and going through 1890, the National League and the American Association faced each other in a series of games at the end of the season to determine an overall champion. These matchups were disorganized in comparison to the modern Series: games played ranged from as few as three in 1884 (Providence defeated New York 3 games to zero), to a high of 15 in 1887 (Detroit beat St. Louis 10 games to 5), and both the 1885 and 1890 Series ended in ties, each team having won three games with one tie game.

Melvin Jerome "Mel" Blanc (May 30, 1908 – July 10, 1989) was an American voice actor and comedian. Although he began his nearly six-decade-long career performing in radio commercials, Blanc is best remembered for his work with Warner Bros. during the "Golden Age of American animation" as the voice of Bugs Bunny, Daffy Duck, Porky Pig, Tweety Bird, Sylvester the Cat, Yosemite Sam, Foghorn Leghorn, Marvin the Martian, Pepé Le Pew, Speedy Gonzales, the Tasmanian Devil, and many of the other characters from the Looney Tunes and Merrie Melodies theatrical cartoons. He later worked for Hanna-Barbera's television cartoons, most notably as the voice of Barney Rubble in The Flintstones and Mr. Spacely in The Jetsons. Having earned the nickname “The Man of a Thousand Voices,” Blanc is regarded as one of the most influential people in the voice-acting industry.

At the time of his death, it was estimated that 20 million people heard his voice every day.

Blanc was born Melvin Jerome Blank in San Francisco, California, to Jewish parents Frederick and Eva Blank. The youngest of two children, he grew up in the neighborhood of Western Addition in San Francisco, and later in Portland, Oregon, attending Lincoln High School. Growing up, he had a fondness for voices and dialect, which he started to do as early as the age of 10. He claimed that when he was 16, he changed the spelling from "Blank" to "Blanc" because a teacher told him that he would amount to nothing and be, like his name, a "blank". Blanc joined The Order of DeMolay as a young man, and was eventually inducted into its Hall of Fame. He dropped out of high school in the ninth grade and split his time between leading an orchestra, becoming the youngest conductor in the country at the time at 17, and performing shtick in vaudeville shows around Washington, Oregon, and northern California.