The Togaviridae are a family of viruses, including the following genera:
The Togaviridae family belong to group IV of the Baltimore classification of viruses. The genome is linear, single-stranded, positive sense RNA that is 10,000-12,000 nucleotides long. The 5'-terminus carries a methylated nucleotide cap and the 3'-terminus has a polyadenylated tail, therefore resembling cellular mRNA. The virus is enveloped and forms spherical particles (65-70 nm diameter), the capsid within is icosahedral, constructed of 240 monomers, having a triangulation number of 4. The receptors for binding are unknown, however the tropism is varied and it is known that the glycoprotein spikes act as attachment proteins. After virus attachment and entry into the cell, gene expression and replication takes place within the cytoplasm. The vector for Togaviridæ is primarily the mosquito, where replication of the virus occurs.
The non-structural proteins are encoded at the 5’ end, formed during the first of two characteristic rounds of translation. These proteins are originally translated as a polyprotein, which consequently undergo self cleavage, forming four non-structural proteins responsible for gene expression and replication. The formation of a sub-genomic fragment, encoding the structural proteins and a negative sense fragment, a template for further synthesis of positive sense RNA are the characteristic second phase of translation. Assembly takes place at the cell surface, where the virus buds from the cell, acquiring the envelope. The replication cycle is very fast, taking around 4 hours.
Ever since the day you came
My life has not been the same
I wanna hear you say my name
The way you, you say it, you say it
Ever since the day you came
My life has not been the same
I wanna hear you say my name
The way you say it, you say it
Lover I just discovered what I love
Lover I just discovered, oh
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That you pass grow to tight
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Called as wise as we see in the sky
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Lover I just discovered what I love
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Lover I just discovered what I love