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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
Vaccines can be prophylactic (example: to prevent or ameliorate the effects of a future infection by any natural or "wild" pathogen), or therapeutic (e.g. vaccines against cancer are also being investigated; see cancer vaccine).
The term vaccine derives from Edward Jenner's 1796 use of cow pox (Latin variola vaccinia, adapted from the Latin vaccīn-us, from vacca, cow), to inoculate humans, providing them protection against smallpox.
Vaccines do not guarantee complete protection from a disease. Sometimes, this is because the host's immune system simply does not respond adequately or at all. This may be due to a lowered immunity in general (diabetes, steroid use, HIV infection, age) or because the host's immune system does not have a B cell capable of generating antibodies to that antigen.
William Henry "Bill" Gates III (born October 28, 1955 in Seattle, Washington) is an American business magnate, computer programmer and philanthropist. Gates is the former chief executive officer (CEO) and current chairman of Microsoft, the world’s largest personal-computer software company he co-founded with Paul Allen. He is consistently ranked among the world's wealthiest people and was the wealthiest overall from 1995 to 2009, excluding 2008, when he was ranked third; in 2011 he was the wealthiest American and the second wealthiest person. During his career at Microsoft, Gates held the positions of CEO and chief software architect, and remains the largest individual shareholder, with 6.4 percent of the common stock. He has also authored or co-authored several books.
Gates is one of the best-known entrepreneurs of the personal computer revolution. Gates has been criticized for his business tactics, which have been considered anti-competitive, an opinion which has in some cases been upheld by the courts. In the later stages of his career, Gates has pursued a number of philanthropic endeavors, donating large amounts of money to various charitable organizations and scientific research programs through the Bill & Melinda Gates Foundation, established in 2000.
Mark Kendall (20 September 1958 – 1 May 2008) was a Welsh footballer who played as a goalkeeper. He represented his country at schoolboy, youth and Under-21 level.
Kendall, a goalkeeper, joined Tottenham Hotspur as an apprentice in March 1975, aged 16. He signed professional forms in July 1976, and went on to make his league debut on 4 November 1978 in a 2-2 draw at Norwich.
However, although he spent four seasons with Spurs, he never managed to make the goalkeeper's position his own. His final full season on the club's books saw him spend a nine-game loan period, during which he saved penalties from Steve Neville of Exeter City and Mark Smith of Sheffield Wednesday, at Division 3 Chesterfield, returning to Tottenham after Barry Daines was injured during an FA Cup-tie against Manchester United.
He signed for Newport County then of Division 3 for a club record £45,000 in September 1980 during the most successful period in the clubs long history. Kendall was part of the team that won promotion and the Welsh Cup and in the subsequent season reached the quarter-final of the 1981 European Cup Winners Cup.
Robert Michael "Rob" Schneider (born October 31, 1963) is an American actor, comedian, screenwriter, and director. A stand-up comic and veteran of the NBC sketch-comedy series Saturday Night Live, Schneider has gone on to a successful career in feature films, including starring roles in the comedy films Deuce Bigalow: Male Gigolo, The Hot Chick, and Grown Ups.
Schneider was born in San Francisco, California and grew up in the nearby suburb of Pacifica. He is the son of Pilar Schneider (née Monroe), a former kindergarten teacher and ex-school board president, and Marvin Schneider, a real estate broker. Schneider's father was Jewish and his mother was Catholic. Schneider's maternal grandmother was a Filipina who met and married Schneider's maternal grandfather, a Caucasian American army private, while he was stationed in the Philippines. Schneider graduated from Terra Nova High School in 1982.
Schneider started his stand-up comedy career while still in high school, opening for San Francisco favorites Head On, a band managed by Rob's older brother John. After high school, he played Bay Area nightclubs such as the Holy City Zoo and The Other Cafe, and was a regular guest on local radio programs. After opening a show by comedian Dennis Miller in 1987, Schneider won a slot on HBO's 13th Annual Young Comedians special, which was hosted by Miller. Schneider's appearance on the HBO special led to a position as a writer for the late night NBC sketch comedy series Saturday Night Live.