Dmitri Ivanovich Mendeleev (also romanized Mendeleyev or Mendeleef; Russian: Дми́трий Ива́нович Менделе́ев  listen (help·info); 8 February [O.S. 27 January] 1834 – 2 February [O.S. 20 January] 1907) was a Russian chemist and inventor. He is credited as being the creator of the first version of the periodic table of elements. Using the table, he predicted the properties of elements yet to be discovered.

Mendeleev was born in the village of Verkhnie Aremzyani, near Tobolsk in Siberia, to Ivan Pavlovich Mendeleev and Maria Dmitrievna Mendeleev (née Kornilieva). His grandfather was Pavel Maximovich Sokolov, a priest of the Russian Orthodox Church from the Tver region. Ivan, along with his brothers and sisters, obtained new family names while attending the theological seminary.

Mendeleev is thought to be the youngest of either 11, 13, 14 or 17 siblings; the exact number differs among sources. His father was a teacher of fine arts, politics and philosophy. Unfortunately for the family's financial well being, his father became blind and lost his teaching position. His mother was forced to work and she restarted her family's abandoned glass factory. At the age of 13, after the passing of his father and the destruction of his mother's factory by fire, Mendeleev attended the Gymnasium in Tobolsk.

Sir Isaac Newton PRS MP (25 December 1642 – 20 March 1727 [NS: 4 January 1643 – 31 March 1727]) was an English physicist, mathematician, astronomer, natural philosopher, alchemist, and theologian, who has been "considered by many to be the greatest and most influential scientist who ever lived." His monograph Philosophiæ Naturalis Principia Mathematica, published in 1687, lays the foundations for most of classical mechanics. In this work, Newton described universal gravitation and the three laws of motion, which dominated the scientific view of the physical universe for the next three centuries. Newton showed that the motions of objects on Earth and of celestial bodies are governed by the same set of natural laws, by demonstrating the consistency between Kepler's laws of planetary motion and his theory of gravitation, thus removing the last doubts about heliocentrism and advancing the Scientific Revolution.

Albert Einstein ( /ˈælbərt ˈaɪnstaɪn/; German: [ˈalbɐt ˈaɪnʃtaɪn] ( listen); 14 March 1879 – 18 April 1955) was a German theoretical physicist who developed the theory of general relativity, effecting a revolution in physics. For this achievement, Einstein is often regarded as the father of modern physics. While best known for his mass–energy equivalence formula E = mc² (which has been dubbed "the world's most famous equation"), he received the 1921 Nobel Prize in Physics "for his services to theoretical physics, and especially for his discovery of the law of the photoelectric effect". The latter was pivotal in establishing quantum theory within physics.

Near the beginning of his career, Einstein thought that Newtonian mechanics was no longer enough to reconcile the laws of classical mechanics with the laws of the electromagnetic field. This led to the development of his special theory of relativity. He realized, however, that the principle of relativity could also be extended to gravitational fields, and with his subsequent theory of gravitation in 1916, he published a paper on the general theory of relativity. He continued to deal with problems of statistical mechanics and quantum theory, which led to his explanations of particle theory and the motion of molecules. He also investigated the thermal properties of light which laid the foundation of the photon theory of light. In 1917, Einstein applied the general theory of relativity to model the structure of the universe as a whole.