Enemy Zero (エネミー・ゼロ^?) is a 1997 survival horror video game for Sega Saturn, developed by WARP and directed by Kenji Eno. After its Saturn release, it was ported to Microsoft Windows. It was the second game to star the digital actress Laura.

In E0, gameplay sequences alternate between interactive FMV and real time exploration, both from a first person perspective. The interactive FMV component uses gameplay identical to an earlier Warp game, D.

The real time component of E0 is unique. Enemies are invisible, and location is only possible through the use of sound, with notes of different pitch helping the player find the distance and direction of enemies. Additionally, every gun in the game must be charged up immediately before each shot, and charging a shot for too long will cause the charge to dissipate, after which the charging must start over. Since all available guns have very limited range, this makes timing crucial; beginning to charge the gun too late or too soon will allow the enemy to reach Laura, resulting in an immediate game over.