HU-331
HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the Cannabis sativa plant. It showed a great efficacy against oncogenic human cells. HU-331 does not cause arrest in cell cycle, cell apoptosis or caspase activation. HU-331 inhibits DNA topoisomerase II even at nanomolar concentrations, but has shown a negligible effect on the action of DNA topoisomerase I. The cannabinoid quinone HU-331 is a very specific inhibitor of topoisomerase II, compared with most known anticancer quinones. One of the main objectives of these studies is the development of a new quinone derived compound that produces anti-neoplastic activity while maintaining low toxicity at therapeutic doses.
Mechanism of action
Inhibitors of topoisomerases can act at two different levels. First inhibiting topoisomerase, which stabilize the topoisomerase-DNA complex and thus introduce DNA breaks in the wires that lead to apoptosis, then inhibiting the catalytic activity of topoisomerase, which hinders the activity of these enzymes without introducing breaks into the DNA chains. HU-331 seems to be a catalytic inhibitor of topoisomerase II, probably by enzymatic ligation to the protein. This molecule does not cause damage to DNA, but protects cells from damage, natural, or induced by other inhibitors of topoisomerase II that act as inhibitors of topoisomerase. Even when 60% of the target cells are killed by treatment with HU-331, other cells' nucleic content remains unharmed, with less breakage of DNA chains that control important cellular functions.
Podcasts:
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by Beck
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by South Park Mexican
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by Snoop Doggy Dog
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by Cya
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by Stiff Little Fingers
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by Michael Franti & Spearhead
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by Blue Scholars
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by Zap Mama
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by Spm
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by Kim Tae Woo
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by Girls' Generation
High 5
by: BeckHigh 5, High 5! High 5, High 5! [rappers]: \" C'mon on! 8! Everybody!
C'mon! 7! C'mon, now! 6! 5!
Aw, yeah, I like that shit.\" When I rock it's like a high 5 Want a slap
in the face I love the taste All my
days with my wheelchair ways Watch me die in my suicide high I don't
mean it 'cause I only come on
to you When I step to the room with a powerful motion Leopard skin let
the records spin 'Round and
round with the speed of sound High 5! More dead than alive! Rocking the
plastic like a man from the
Catskills! High 5! More dead than alive! Rocking the plastic like a
man from the Catskills! Rocky
mountain low we gotta go Put that gadget in the random mode Cripple
candy rocking the candy
Rhumba, brickshot, doing the foxtrot In my car sweating like a dog Beers
and chairs no fronteirs On my
way from the 'Frisco Bay Dixieland, soda-pop man High 5! More dead than
alive! Rocking the plastic
like a man from the Catskills! High 5! More dead than alive! Rocking
the plastic like a man from the
Catskills! [spoken]:Yeah, put that machine in random mode Talking about
popping jugger Like the last
century [Mike D]: \"Turn that shit off, man! What's wrong with you? Man,
get the other record! Damn!\"
High 5! More dead than alive! Rocking the plastic like a man from the
Catskills! High 5! More dead
than alive! Rocking the plastic like a man from the Catskills! High 5!
More dead than alive! Rocking the
plastic like a man from the Catskills! High 5! More dead than alive!
Rocking the plastic like a man from
the Catskills! [Mike D]: \"Ok, now. Do like designer jeans. Everybody,
designer jeans! say, say, say,
say, say: Ooh, la la, sasoon! C'mon, c'mon, c'mon! Everybody! One more
time, let me hear you say:
Ooh, la la, sasoon! Just do it everybody, c'mon! Now I want the
ladies. All the ladies, say: Sergio
Valente! Sing it, girl.
Let me hear you say: Sergio Valente!