Messenger RNA (mRNA) is a molecule of RNA that encodes a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis, the ribosomes. In the ribosomes, the mRNA is translated into a polymer of amino acids: a protein. (This process is sometimes referred to as the central dogma of molecular biology.)

As in DNA, mRNA genetic information is encoded in the sequence of nucleotides, which are arranged into codons consisting of three bases each. Each codon encodes for a specific amino acid, except the stop codons, which terminate protein synthesis. This process of translation of codons into amino acids requires two other types of RNA: Transfer RNA (tRNA), that mediates recognition of the codon and provides the corresponding amino acid, and ribosomal RNA (rRNA), that is the central component of the ribosome's protein-manufacturing machinery.

The brief existence of an mRNA molecule begins with transcription, and ultimately ends in degradation. During its life, an mRNA molecule may also be processed, edited, and transported prior to translation. Eukaryotic mRNA molecules often require extensive processing and transport, while prokaryotic molecules do not.

Marco Polo (ⁱ/ˈmɑrkoʊ ˈpoʊloʊ/; Italian pronunciation: [ˈmarko ˈpɔːlo]; c. 1254 – January 9, 1324) was a Venetian merchant traveler from the Venetian Republic whose travels are recorded in Il Milione, a book which did much to introduce Europeans to Central Asia and China. He learned about trading whilst his father and uncle, Niccolò and Maffeo, travelled through Asia and apparently met Kublai Khan. In 1269, they returned to Venice to meet Marco for the first time. The three of them embarked on an epic journey to Asia, returning after 24 years to find Venice at war with Genoa; Marco was imprisoned, and dictated his stories to a cellmate. He was released in 1299, became a wealthy merchant, married and had three children. He died in 1324, and was buried in San Lorenzo.

Their pioneering journey inspired Christopher Columbus and others. Marco Polo's other legacies include Venice Marco Polo Airport, the Marco Polo sheep, and several books and films. He also had an influence on European cartography, leading to the introduction of the Fra Mauro map.