"Yakety Sax" is a piece of music written by James Q. "Spider" Rich and Boots Randolph and popularized by saxophonist Randolph in his 1963 recording.

The composition includes pieces of assorted fiddle tunes such as "Chicken Reel", and was written for a performance at a venue called The Armory in Hopkinsville, Kentucky. Two bars of "Entrance of the Gladiators" are also worked into it.

The song is not to be confused with the Leiber and Stoller song "Yakety Yak", recorded in 1958 by The Coasters. The tunes are similar, and both feature the "yakety sax" sound, but have distinct melodies. Randolph first recorded "Yakety Sax" that year for RCA Victor, but the song did not become a hit until his re-recording for Monument Records in 1963, which reached #35 on the Billboard Hot 100 chart.

"Yakety Sax" is often used in television and film as a soundtrack for outlandishly humorous situations. It was frequently used to accompany comedic sketches in the comedy programme The Benny Hill Show, where it accompanied otherwise silent, rapidly paced comedy sequences typically involving a farcical chase scene. This use of the piece, and the chase scenes themselves, have been parodied in many other movies and TV shows, including the 2006 British film, V for Vendetta. The cartoon South Park also used the piece in one episode.