Hexane is a hydrocarbon with the chemical formula C₆H₁₄; that is, an alkane with six carbon atoms.

The term may refer to any of four other structural isomers with that formula, or to a mixture of them. In the IUPAC nomenclature, however, hexane is the unbranched isomer (n-hexane); the other four structures are named as methylated derivatives of pentane and butane. IUPAC also uses the term as the root of many compounds with a linear six-carbon backbone, such as 2-methylhexane C₇H₁₆, which is also called "isoheptane".

Hexanes are significant constituents of gasoline. They are all colorless liquids at room temperature, with boiling points between 50 and 70 °C, with gasoline-like odor. They are widely used as cheap, relatively safe, largely unreactive, and easily evaporated non-polar solvents.

In industry, hexanes are used in the formulation of glues for shoes, leather products, and roofing. They are also used to extract cooking oils from seeds, for cleansing and degreasing a variety of items, and in textile manufacturing.