The Neo-Assyrian Empire was an empire in Mesopotamian history which began in 934 BC and ended in 605 BC. During this period, Assyria assumed a position as the most powerful nation on earth, successfully eclipsing Babylonia, Egypt, Urartu/Armenia and Elam for dominance of the Near East, Asia Minor, Caucasus, North Africa and east Mediterranean, though not until the reforms of Tiglath-Pileser III in the 8th century BC did it become a vast empire. Assyria was originally an Akkadian kingdom which evolved in the 25th to 24th Centuries BC. The earliest Assyrian kings such as Tudiya were relatively minor rulers, and after the founding of the Akkadian Empire, which lasted from 2334 BC to 2154 BC, these kings became subject to Sargon of Akkad, who united all the Akkadian and Sumerian speaking peoples of Mesopotamia under one rule.

Ashur-nasir-pal II (transliteration: Aššur-nāṣir-apli, meaning "Ashur is guardian of the heir") was king of Assyria from 883 to 859 BC.

Ashurnasirpal II succeeded his father, Tukulti-Ninurta II, in 883 BC. During his reign he embarked on a vast program of expansion, first conquering the peoples to the north in Asia Minor as far as Nairi and exacting tribute from Phrygia, then invading Aram (modern Syria) conquering the Aramaeans and neo Hittites between the Khabur and the Euphrates Rivers. His harshness prompted a revolt that he crushed decisively in a pitched, two-day battle. According to his monument inscription while recalling this massacre he says "their men young and old I took prisoners. Of some I cut off their feet and hands; of others I cut off the ears noses and lips; of the young men's ears I made a heap; of the old men's heads I made a marinet. I exposed their heads as a trophy in front of their city. The male children and the female children I burned in flames; the city I destroyed, and consumed with fire." Following this victory, he advanced without opposition as far as the Mediterranean and exacted tribute from Phoenicia. On his return back home he moved his capital to the city of Kalhu (Nimrud).

Cyrus II of Persia (Old Persian: Kuruš (c. 600 BC or 576 BC–530 BC), commonly known as Cyrus the Great, also known as Cyrus the Elder, was the founder of the Achaemenid Empire. Under his rule, the empire embraced all the previous civilized states of the ancient Near East, expanded vastly and eventually conquered most of Southwest Asia and much of Central Asia, parts of Europe and the Caucasus. From the Mediterranean sea and Hellespont in the west to the Indus River in the east, Cyrus the Great created the largest empire the world had yet seen. He also pronounced one of the first historically important declarations of human rights via the Cyrus Cylinder sometime between 539-530 BCE.

The reign of Cyrus the Great lasted between 29 and 31 years. Cyrus built his empire by conquering first the Median Empire, then the Lydian Empire and eventually the Neo-Babylonian Empire. Either before or after Babylon, he led an expedition into central Asia, which resulted in major campaigns that were described as having brought "into subjection every nation without exception". Cyrus did not venture into Egypt, as he himself died in battle, fighting the Massagetae along the Syr Darya in December 530 BC. He was succeeded by his son, Cambyses II, who managed to add to the empire by conquering Egypt, Nubia, and Cyrenaica during his short rule.