The Mixtec (or Mixteca) are indigenous Mesoamerican peoples inhabiting the Mexican states of Oaxaca, Guerrero and Puebla in a region known as La Mixteca. The Mixtecan languages form an important branch of the Otomanguean language family.

The term Mixtec (Mixteco in Spanish) comes from the Nahuatl word mixtecah, "cloud people" . The area in which Mixtec is spoken is known as the Mixteca. The Mixtecs call themselves ne'ivi davi; they call their region Ñuu Savi, Ñuu Djau, Ñuu Davi, etc., depending on the local variant of their language; they call their language sa'an davi, da'an davi or tu'un savi.

In pre-Columbian times, the Mixtec were one of the major civilizations of Mesoamerica. Important ancient centres of the Mixtec include the ancient capital of Tilantongo, as well as the sites of Achiutla, Cuilapan, Huajuapan, Mitla, Tlaxiaco, Tututepec, Juxtlahuaca, and Yucuñudahui. The Mixtec also made major constructions at the ancient city of Monte Albán (which had originated as a Zapotec city before the Mixtec gained control of it). The work of Mixtec artisans who produced work in stone, wood, and metal were well regarded throughout ancient Mesoamerica.