A carcinogen is any substance, radionuclide, or radiation that is an agent directly involved in causing cancer. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise in both natural and synthetic substances.

Cancer is a disease in which damaged cells do not undergo programmed cell death. Carcinogens may increase the risk of cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with biological processes, and induces the uncontrolled, malignant division, ultimately leading to the formation of tumors. Usually DNA damage, if too severe to repair, leads to programmed cell death, but if the programmed cell death pathway is damaged, then the cell cannot prevent itself from becoming a cancer cell.

In the English language, black sheep is an idiom used to describe an odd or disreputable member of a group, especially within a family. The term has typically been given negative implications, implying waywardness. It derived from the atypical and unwanted presence of other black individuals in flocks of white sheep.

In psychology, the black sheep effect refers to the tendency of group members to judge likeable ingroup members more positively and deviant ingroup member more negatively than comparable outgroup members.

The term originated from the occasional black sheep which are born into a flock of white sheep due to a genetic process of recessive traits. Black wool was considered commercially undesirable because it could not be dyed. In 18th and 19th century England, the black color of the sheep was seen as the mark of the devil. In modern usage, the expression has lost some of its negative connotations, though the term is usually given to the member of a group who has certain characteristics or lack thereof deemed undesirable by that group.