Keihanshin (京阪神^?, "Kyoto-Osaka-Kobe") is a Japanese metropolitan region encompassing the metropolitan areas of the cities of Osaka in Osaka prefecture, Kobe in Hyōgo Prefecture, and Kyoto in Kyoto prefecture. The entire region has a population (as of 2000) of 18,644,000 over an area of 11,170 km². It is Japan's second most populated urban region after the Greater Tokyo Area, containing approximately 15% of Japan's population.

The GDP in this area (Osaka and Kobe) is $341 billion, making it one of the world's most productive regions, a match with Paris and London.Mastercard Worldwide reported that Osaka is the 19th ranking city of the world's leading global cities and has an instrumental role in driving the global economy.

The name Keihanshin is constructed by extracting a representative kanji from Kyoto (京都), Osaka (大阪), and Kobe (神戸), but using the On-yomi (Chinese reading) instead of the corresponding Kun-yomi (Japanese reading) for each of the characters taken from Osaka and Kobe, and the kan-on Chinese reading of the character for Kyoto instead of the usual go-on Chinese reading.