Acámbaro is a city and municipality in the southeastern corner of the Mexican state of Guanajuato, on the banks of the Lerma River, and the oldest of the 46 municipalities of Guanajuato. Acámbaro is noted as a major railway junction, a local transport hub, and the origin of the nationally famous Acámbaro bread. The current (2005 census) population of the municipality is 101,762 persons, that of the city proper 55,082. The municipality covers an area of 867.67 km² (335.01 sq mi) and includes many small outlying communities, the largest of which are Iramuco and Parácuaro.
The municipality of Acámbaro is bordered to the north by Tarimoro and Jerécuaro, to the southeast by Tarandacuao, to the south by the state of Michoacán, and to the west by Salvatierra.
The name Acámbaro is derived from a Native American term meaning place of magueyes. The first inhabitants of this area belonged to the Chupicuaro culture, one of the oldest in Mesoamerica. Their origin is estimated to be from 1200 B.C. In this region there have been valuable archaeological finds of ceramic of incredible beauty that are now exhibited at the local museum.