Debreceni VSC (Hungarian pronunciation: [ˈdɛbrɛt͡sɛni veː ɛʃ t͡seː]) or just Debrecen or DVSC is a football club from the city of Debrecen in Hungary. They are best known for reaching the group stages of the UEFA Champions League 2009–10 season. Debreceni VSC has been the most successful Hungarian club since 2000. The club has won the Hungarian League six times in 2005, 2006, 2007, 2009, 2010 and 2012. The club's nickname is Loki (Lokomotiv), from its long-standing ties to the railways.

The club was founded on 12 March 1902, initially being known as "Egyetértés Futball Club" but on becoming independent it was renamed "Debreceni Vasutas Sport Club" (Debrecen Railway Sports Club). In 1926 professionalism came to the Hungarian football scene, with the unfortunate result that "Bocskay FC" was formed using players from DVSC and city rivals DKASE and DTE, with the result that Bocskay ruled the football roost in Debrecen for 15 years while DVSC continued to struggle in the lower divisions. In 1940 the professional/amateur division of players was abolished and Bocskay suffered financial collapse, returning DVSC to top-dog position in the city. Debrecen reached the Hungarian First Division for the first time in 1942–43, but then suffered something of a yo-yo existence for the next fifty years, suffering eight relegations in all, and even starting the 1967 season in the Third Division. During this period the club underwent a number of name changes. It became "Debreceni Vasutas Sport Egyesület" in 1948–49, "Debreceni Lokomotiv" (hence the nickname) in 1949, "Debreceni Törekvés" in the 1955–56 season, and it was known as "Debreceni Vasutas SC" from 1957 to 1979. In 1979 the two city teams, DVSC and DMTE were united into one team, called DMVSC, but after ten years the clubs split again and the team adopted its current name.