UFC 110: Nogueira vs. Velasquez was a mixed martial arts event held by the Ultimate Fighting Championship (UFC) on Sunday, 21 February 2010 in Sydney, Australia, at Acer Arena. The event marked the UFC's first trip to Australia. The main card was scheduled for 2:00 pm Sunday in Sydney to cater to the U.S. audience, meaning that the event took place at the regular U.S. time (10:00 pm ET, on Saturday 20 February).

The event drew 17,431 fans, a sell out of A$2.5 million. 400 tickets were sold to a closed circuit viewing party at the Arena's Ballroom, making the number of total fans inside the building 17,831. The event grossed $540,000 in merchandise sales, breaking the previous record of $498,000 at UFC 83. Total sales topped the previous Acer Arena record held by Iron Maiden.

The long expected bout between Yoshihiro Akiyama and Wanderlei Silva did not take place at this event. Instead, Silva faced Michael Bisping.

A bout between Nate Marquardt and Chael Sonnen which was expected to take place on this card was moved to UFC 109. A bout between Keith Jardine and Rich Franklin had been discussed, but Jardine eventually fought the Ultimate Fighter 8 winner Ryan Bader.

Wanderlei César da Silva ( /ˈvændərleɪ/ VAN-dər-lay; Portuguese: [vɐ̃dɛɾˈlej ˈsɛzɐr dɐ ˈsiɫvɐ];Japanese: [ba̠nda̠ɽe̞i ɕiü͍βa̠]; born July 3, 1976), nicknamed "The Axe Murderer", is a Brazilian mixed martial artist, who has competed in Japan's Pride Fighting Championships and the American based Ultimate Fighting Championship (UFC). Silva is known for his aggressive fighting style with the majority of his fights ending in knockout or referee stoppage due to strikes. His style includes engaging opponents with punches and knees from the Muay Thai clinch. He holds the record for the most wins and knockouts in Pride FC history. He is currently ranked as #22 best middleweight fighter in the world by FightMatrix.com.

Silva began his training under Rudimar Fedrigo at the Chute Boxe Academy in his hometown of Curitiba, Brazil. Although he specializes in muay Thai, he has also trained and received his black belt in Brazilian jiu-jitsu from trainer Cristiano Marcello. Silva was given the nickname "Cachorro Louco" ("Mad Dog") in Brazil because of his aggressive style and his pre-fight opponent "stare down". He is the former IVC Light heavyweight Champion, former PRIDE Middleweight Champion, and the 2003 PRIDE Middleweight Grand Prix Tournament Winner.

Cain Velasquez Ramirez (born July 28, 1982) is a Mexican American mixed martial artist fighting in the Ultimate Fighting Championship where he is a former UFC Heavyweight Champion. He is a two-time All-American collegiate wrestler from Arizona State University in Tempe, Arizona, and a Junior College National Champ at Iowa Central Community College. He is a two-time 5A state champion in Arizona, compiling a record of 110–10 for Kofa High School in Yuma, Arizona. Cain Velasquez is ranked #2 in the heavyweight division.

Velasquez, a Mexican American, was born on July 28, 1982 in Salinas, California to Efrain and Isabel Velasquez. Velasquez's father, Efrain, came from Mexico to the United States illegally. Efrain met his wife Isabel, married her, and gained US citizenship. Velasquez has two siblings, Efrain, Jr., and Adela. He was raised in Yuma, Arizona. He graduated from Kofa High School, where he compiled a record of 110–10 in four years of wrestling, including winning the 5A Arizona Wrestling Championship twice. Velasquez also played football for three years. As a senior, he served as Captain of both his wrestling and football teams.

Michael Gavin Joseph Bisping (born 28 February 1979) is an English mixed martial artist. He fights in the middleweight division of the Ultimate Fighting Championship and is the former Cage Warriors Fighting Championship Light Heavyweight Champion, former Cage Rage Light Heavyweight Champion and The Ultimate Fighter 3 Light Heavyweight Tournament winner. As of March 2012, Bisping is ranked the No. 4 middleweight in the world by Sherdog.

Bisping was born in manchester UK in 1979, but moved to Bridlington, East Yorkshire, England when he was a child. Taking an early interest in martial arts, Bisping began training in a traditional form of jiu-jitsu known as Yawara Ryu under Paul Lloyd Davies when he was 8 years old. In 1994, at the age of 15, Bisping competed as an amateur in England's first "no holds barred" competition, a precursor to modern MMA, called Knock Down Sport Budo (KSBO), organised by Davies.

At the age of 18, Bisping decided to abandon his martial arts training in order "to pursue real life". But less than a year later Bisping began training kickboxing and karate on the advice of Alan Clarking, owner of Black Knights gym, who saw potential in the young fighter. Bisping enjoyed a short, but successful kickboxing career, winning the North West Area title and later the Pro British light heavyweight kickboxing title. After again briefly quitting competition in 1998, Bisping returned to kickboxing to take the Pro British light heavyweight title for a second time. Soon after winning his second kickboxing title, Bisping was forced to abandon his full-time training for a "real job". Bisping worked in factories, slaughterhouses, as an upholsterer, a postman, a tiler, a plasterer, a double-glazing door salesman,production line operative making barbecues at Rectella in Clitheroe and also a relatively successful DJ around the north-west club scene.

Michael Joe Whitehead (born June 29, 1981) is a former professional mixed martial arts (MMA) fighter. He has fought in the light heavyweight and heavyweight weight classes for the UFC, IFL, Affliction, and Strikeforce.

Mike Whitehead started wrestling at North Idaho JC, Southern Oregon University, and Missouri. He is a 3 time All American Wrestler and Abu Dhabi qualifier. In 2005, he participated in the The Ultimate Fighter 2 reality series on Spike TV.

He is 27-7 in his MMA career. Prior to his fight with Renato Sobral, he was on a 13 fight win streak, including five straight victories in the IFL. He has proven himself dangerous standing and striking, as well as with wrestling and submission grappling.

He has also competed in the standup only fight organization Xtreme Fighting Association where he defeated Ethen Cox by unanimous decision.

Whitehead was arrested by Las Vegas Metro Police on April 14, 2010, after a female acquaintance filed a report that he had sexually assaulted her at his home. He faces several charges including two counts of sexual assault and one count each of attempted sexual assault and open and gross lewdness. Additional charges could still be coming for Mike based on the marijuana grow operation detectives found when they went to serve a warrant in response to the sexual assault. Detectives found 50 marijuana plants inside the residence, all of which were confiscated and destroyed after they were granted a warrant for the plants.