L-DOPS (L-threo-dihydroxyphenylserine; Droxidopa; SM-5688) is a psychoactive drug and synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Unlike norepinephrine and epinephrine themselves, L-DOPS is capable of crossing the protective blood–brain barrier (BBB).

L-DOPS was developed by Sumitomo Pharmaceuticals under the trade name Droxidopa for the treatment of hypotension, including NOH, and NOH associated with various disorders such as MSA, FAP, and PD, as well as IDH. The drug has been used in Japan and some surrounding Asian areas for these indications since 1989. Following a merge with Dainippon Pharmaceuticals in 2006, Dainippon Sumitomo Pharma licensed L-DOPS to Chelsea Therapeutics to develop and market it worldwide except in Japan, Korea, China, and Taiwan.

Though L-DOPS has been used in Japan and Southeast Asia already for some time, it is also currently in clinical trials at the phase III point in the United States (U.S.), Canada, Australia, and throughout Europe. Provided L-DOPS successfully completes clinical trials, it could be approved for the treatment of NOH as early as 2011. Additionally, phase II clinical trials for IDH are also underway. Chelsea Therapeutics obtained orphan drug status (ODS) for L-DOPS in the U.S. for NOH, and that of which associated with PD, PAF, and MSA, and is the pharmaceutical company developing it in that country.

Amy Jade Winehouse (14 September 1983 – 23 July 2011) was an English singer and songwriter known for her powerful deep contralto vocals and her eclectic mix of musical genres including R&B, soul and jazz. Winehouse's 2003 debut album, Frank, was critically successful in the UK and was nominated for the Mercury Prize. Her 2006 follow-up album, Back to Black, led to six Grammy Award nominations and five wins, tying the then record for the most wins by a female artist in a single night, and made Winehouse the first British female to win five Grammys, including three of the "Big Four": Best New Artist, Record of the Year and Song of the Year.

In 2007 she won a Brit Award for Best British Female Artist; she had also been nominated for Best British Album. She won the Ivor Novello Award three times: once in 2004 for Best Contemporary Song (musically and lyrically) for "Stronger Than Me", once in 2007 for Best Contemporary Song for "Rehab", and once in 2008 for Best Song Musically and Lyrically for "Love Is a Losing Game".