The Mexican Cession of 1848 is a historical name in the United States for the region of the present day southwestern United States that Mexico ceded to the U.S. in the Treaty of Guadalupe Hidalgo in 1848, but had not been part of the areas east of the Rio Grande which had been claimed by the Republic of Texas, though the Texas Annexation resolution two years earlier had not specified Texas's southern and western boundary.

Most of the area had been the Mexican territory of Alta California, while a southeastern strip on the Rio Grande had been part of Santa Fe de Nuevo México, most of whose area and population were east of the Rio Grande on land that had been claimed by the Republic of Texas since 1835, but never controlled or even approached aside from the Texas Santa Fe Expedition. Mexico controlled the territory later known as the Mexican Cession, with considerable local autonomy punctuated by several revolts and few troops sent from central Mexico, in the period from 1821-2 after independence from Spain up through 1846 when U.S. military forces seized control of California and New Mexico on the outbreak of the Mexican-American War. The northern boundary of the 42nd parallel north was set by the Adams–Onís Treaty signed by the U.S. and Spain in 1821 and ratified by Mexico in 1831. The eastern boundary of the Mexican Cession was the Texas claim at the Rio Grande and extending north from the headwaters of the Rio Grande, not corresponding to Mexican territorial boundaries. The southern boundary was set by the Treaty of Guadalupe Hidalgo, which followed the Mexican boundaries between Alta California (to the north) and Baja California and Sonora (to the south).

Mexican Americans are Americans of Mexican descent. As of July 2009, Mexican Americans make up 10.3% of the United States' population with over 31,689,000 Americans listed as of Mexican ancestry. Mexican Americans comprise 66% of all Hispanics and Latinos in the United States. The United States is home to the second largest Mexican community in the world second only to Mexico itself comprising nearly 22% of the entire Mexican origin population of the world. Canada is a distant third with a Mexican origin population of 37,000 as of 2001 although increasing to 61,505 as of 2006. In addition, as of 2008 there were approximately 7,000,000 undocumented Mexicans living in the United States which if included in the count would increase the US share to over 28% of the world's Mexican origin population (Note that some of the undocumented would be captured in the US Census count depending on their willingness to provide information). Over 60% of all Mexican Americans reside in the states of California and Texas. Most Mexican Americans are the descendants of the Indigenous peoples of Mexico and/or Europeans, especially Spaniards.