Rhône-Alpes (French pronunciation: [ron.alp] ( listen); Arpitan: Rôno-Arpes; Occitan: Ròse-Aups) is one of the 27 regions of France, located on the eastern border of the country, towards the south. The region was named after the Rhône River and the Alps mountain range. Its capital, Lyon, is the second-largest metropolitan area in France after Paris. Rhône-Alpes has the sixth-largest economy of any European region.

Rhône-Alpes is located in the east of France. To the north are the French regions of Bourgogne (Burgundy) and Franche-Comté, to the west it borders the region Auvergne, to the south it borders Languedoc-Roussillon and Provence-Alpes-Côte d'Azur. The east of the region contains the westernmost part of the Alps and borders Switzerland and Italy. The highest peak is Mont Blanc, on the French-Italian border. The central part of the region comprises the river valleys of the Rhône and the Saône. The confluence of these two rivers is at Lyon. The western part of the region contains the start of the Massif Central mountain range. The region also borders or contains major lakes such as Lake Geneva (Lac Léman) and Lake Annecy. The Ardèche River flows through the southwest portion of the region, where it has carved the deepest gorge in Europe.