Meurthe-et-Moselle (French pronunciation: [mœʁte mɔzɛl]) is a department in the Lorraine region of France, named after the Meurthe and Moselle rivers.

Meurthe-et-Moselle was created in 1871 at the end of the Franco-Prussian War from the parts of the former departments of Moselle and Meurthe which remained French territory.

The current boundary between Meurthe-et-Moselle and Moselle was the border between France and Germany from 1871 to 1919 and again between 1940 and 1944. The only subsequent change took place in 1997 and involved the incorporation, for administrative reasons, of the little commune of Han-devant-Pierrepont which had previously fallen within the Meuse department.

Meurthe-et-Moselle is part of the region of Lorraine and is surrounded (counter-clockwise) by the departments of Meuse, Vosges, Bas-Rhin, and Moselle; and by the nations of Luxembourg and Belgium. Parts of Meurthe-et-Moselle belong to Parc naturel régional de Lorraine.

Its extends from north to south for 130 kilometers and between 7 and 103 kilometers from west to east.