North Hollywood is a district in the San Fernando Valley region of the city of Los Angeles, California, along the Tujunga Wash. It is bounded on the south by Moorpark Street and the Ventura Freeway, on the southwest by Burbank Blvd. and Coldwater Canyon Ave., on the northwest by Tonopah St., on the northeast by Laurel Canyon Blvd./ Webb Ave./ Lankershim Blvd., Sherman Way, and on the east by Clybourn Ave. The Hollywood Freeway (California Highway 170) runs north-south through the middle of it. North Hollywood was established by the Lankershim Ranch Land and Water Company in 1887. It was first named Toluca before being renamed Lankershim in 1896 and finally North Hollywood in 1927. It is home to the NoHo Arts District.

North Hollywood was once part of the vast landholdings of the Elizabethian Mission San Fernando Rey de España, which were confiscated by the government during the Mexican period of rule.

Following the outbreak of the Mexican-American War, a small group of Yankees^{[clarification needed]} raised the California Bear Flag on June 18, 1846 and declared independence from Mexico. United States troops quickly took control of the presidios at Monterey and San Francisco and proclaimed the conquest complete. In Southern California, the Mexicans, for a time, resisted American troops, but when defeat became inevitable, Andrés Pico arranged the peaceful surrender of Los Angeles to American forces under Lieutenant-Colonel John C. Frémont. Pico and Frémont signed the Treaty of Cahuenga which ended the U.S.-Mexican fighting in California was signed at Tomás Feliz's adobe house at Campo de Cahuenga on on today's Lankershim Boulevard in January 1847.

Hollywood is a district in Los Angeles, California, United States situated west-northwest of downtown Los Angeles. Due to its fame and cultural identity as the historical center of movie studios and movie stars, the word Hollywood is often used as a metonym of American cinema. Today, much of the movie industry has dispersed into surrounding areas such as the Westside neighborhood, and the San Fernando and Santa Clarita Valleys, but significant auxiliary industries, such as editing, effects, props, post-production, and lighting companies remain in Hollywood, as does the backlot of Paramount Pictures.

On February 16, 2005, California Assembly Members Jackie Goldberg and Paul Koretz introduced a bill to require California to keep specific records on Hollywood as if it were independent, although it is not the typical practice of the City of Los Angeles to establish specific boundaries for districts or neighborhoods. For this to be done, the boundaries were defined. The bill was unanimously supported by the Hollywood Chamber of Commerce and the Los Angeles City Council. Assembly Bill 588 was approved by the Governor of California on August 28, 2006, and now the district of Hollywood has official borders. The border can be loosely described as the area east of West Hollywood, south of Mulholland Drive, Laurel Canyon, Cahuenga Boulevard, and Barham Boulevard, and the cities of Burbank and Glendale, north of Melrose Avenue and west of the Golden State Freeway and Hyperion Avenue. This includes all of Griffith Park and Los Feliz^{[citation needed]} – two areas that were hitherto considered separate from Hollywood by most Angelenos. The population of the district, including Los Feliz, as of the 2000 census was 123,436 and the median household income was $33,409 in 1999.