Transcortin

Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.

Function

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors (serpins) which have evolved by duplication events.

Binding

Transcortin binds several steroid hormones at high rates:

Cortisol - Approximately 75% of the cortisol in circulation is bound to transcortin. (The rest is bound to serum albumin.) Cortisol is thought to be biologically active only when it is not bound to transcortin.

Cortisone

Deoxycorticosterone (DOC)

Corticosterone - About 78% of serum corticosterone is bound to transcortin.

Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound to serum albumin. The remaining 36% is free.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Transcortin

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Transcortin

Function

Binding

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